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“Intention to Treat,” hosted by health care journalist Rachel Gotbaum, draws on the world-class expertise of the New England Journal of Medicine to present breaking news and incisive analysis of critical and timely issues in medicine and health care. Through interviews with NEJM editors, specialized experts, physicians, and affected patients, each episode explores a story-behind-the-story, giving listeners needed context and a deeper understanding of complex research, cutting-edge medical interventions, and urgent health policy debates that affect patients and the clinicians who care for them. Practicing clinicians, biomedical researchers, medical trainees, patients, and anyone with an interest in health will find unique insights in “Intention to Treat.”
31 Episodes
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This episode examines CAR T-cell therapy’s early successes, broader promise, and emerging risks, as the FDA considers reports of occasional secondary cancers.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2400701.
This episode explores the fastest-growing neurologic condition in the world, Parkinson’s disease. What have we learned in recent years, and where are the greatest hopes for the future?
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2414003.
In this episode, parents who have lost children to gun accidents and physicians working for gun safety discuss the number-one killer of U.S. children and what doctors can do about it.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2314002.
This episode of “Intention to Treat” tells the story of the Freedom House Ambulance Service — a group of Black laypeople in Pittsburgh who underwent intensive training to become the first paramedics in the United States. [Originally aired on May 4, 2023.]
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2303614.
Highlighting gaps in communication near the end of life, this podcast episode explores a new approach to preparing patients with serious illness and their families for all possible outcomes.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2314001.
In the second half of our podcast series on historical injustices, guests Evelynn Hammonds and David Jones examine the racism of post-World War II American medicine and its lessons for the present day.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2314000.
Over its 200-plus years, the Journal has sometimes published articles that have perpetuated injustices against various groups of people. A new Perspective series explores that history and its lessons.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2311329.
This episode examines Covid-19 variants that are currently circulating, recommendations for booster shots, and new treatments in the pipeline.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2311327.
This episode examines the need for and promise of xenotransplantation, considering first the plight of patients and then the progress being made by researchers.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2309946.
This episode explores the current state of research on the multiple likely mechanisms of Alzheimer’s disease as well as promising treatments and diagnostics.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2309944.
Host Rachel Gotbaum talks with a patient with early-onset Alzheimer’s disease and two dementia experts about frustrations with the current state of Alzheimer’s care.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2309485.
This episode explores long Covid, an often-disabling but unexplained syndrome of post-acute sequelae of SARS-CoV-2. How is it affecting millions of people, and what is being done about it?
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2309483.
1This episode peers into U.S. schools to examine a widespread but non–evidence-based approach to preparing children and staff for gun-violence incidents.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2308309.
In this episode, a patient with narcolepsy describes her rough, long road to diagnosis and treatment, and a researcher elucidates both the condition and a new therapeutic direction.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2308308.
Cardiologists now recognize that heart failure with preserved ejection fraction (HFpEF) may be caused by obesity. This episode of “Intention to Treat” examines new evidence that treating obesity can prevent HFpEF.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2307349.
People living with HIV have increased risk for cardiovascular disease (and other diseases of aging) earlier in life than those without HIV. In this episode of “Intention to Treat,” researcher Steven Grinspoon describes a new strategy for preventing collateral damage.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2307347.
Some types of pain have proven resistant to all available medications. In this episode of “Intention to Treat,” Rachel Gotbaum talks with a patient with neuropathic pain and a researcher exploring new sodium-channel blockers that offer promise for such patients.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2305759.
What is driving U.S. physicians out of primary care — and keeping trainees from going into it in the first place? In this episode of “Intention to Treat,” host Rachel Gotbaum explores the breakdown of the system and possible ways to save it.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2305758.
This episode of “Intention to Treat,” explores the crisis in primary care in the United States, as increasing numbers or primary care physicians leave the field — driven out by corporatization, growing time pressure, and the inability to form the relationships that enable good care.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2303852.
In this episode of “Intention to Treat,” host Rachel Gotbaum explores the story of a teenager who’s now in remission from previously relapsed lymphoblastic leukemia and talks with the investigator who developed the “off-the-shelf” CAR T cells that made her treatment possible.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2303851.
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