Science (Audio)

Advances in precision medicine and patient advocacy are transforming the way cancer is understood and treated. Nikoo McGoldrick shares her personal journey with metastatic breast cancer, emphasizing the importance of patients having a voice in their care. Sheldon Morris, M.D., M.P.H., explains how regenerative medicine progresses through stem cell therapies, gene therapies, CAR-T cell treatments, and small molecules, with clinical trials addressing cancer, autoimmune disorders, and neurological diseases. Sandip Patel, M.D., F.A.S.C.O., highlights cancer stem cells as key drivers of relapse and resistance, describing precision medicine approaches, novel CAR-T therapies, and the role of artificial intelligence in cancer detection and treatment. Rebecca Shatsky, M.D., focuses on breast cancer as a systemic disease linked to dormant cancer stem cells, underscoring the need for genomic and immune-based therapies, including innovative antibody treatments and targeted clinical trials. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40910]

Scott A. Armstrong, M.D., Ph.D., of the Dana-Farber Cancer Institute, studies how certain aggressive forms of acute myeloid leukemia (AML) develop and survive. His work centers on a protein called menin, which helps leukemia cells keep cancer-promoting genes switched on. Armstrong’s team has found that blocking menin with specially designed drugs can shut down these gene programs, push leukemia cells to mature, and slow or stop the disease in lab models and patients. While some leukemias adapt by developing mutations in menin or finding other ways to survive, his research is revealing why certain genes are especially dependent on menin and how to target them more effectively. These discoveries are now shaping new treatments, drug combinations, and potential strategies for other cancers that rely on similar mechanisms. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40875]

For many people, a personal connection to the ocean ties into bigger issues like conservation and climate change. As the biodiversity of marine life along the coast at La Jolla Shores has declined, divers and researchers discuss why simply knowing about environmental problems isn’t enough. They emphasize the importance of conservation psychology, storytelling, and inspiration to encourage action. This video was created by graduate students in Marine Biodiversity & Conservation at Scripps Institution of Oceanography, UC San Diego. [Science] [Show ID: 41072]

Why does amber light ease stress and anxiety? One theory is that it’s similar to the natural orange light experienced in nature, like sunsets and campfires. Thanks to interest and funding in color psychology research, discoveries like this will improve emotional and mental health for everyone, especially those who need it most like hospital patients and those in elder care housing. Series: "UC Davis News" [Health and Medicine] [Science] [Show ID: 41054]

Coastal Santa Barbara is considered one of the most idyllic locations on the North American West Coast, but its beauty is frequently disrupted by fast-spreading, wind-driven wildfires. The east-west oriented Santa Ynez Mountains (SYM), rising abruptly over 1,000 meters from the coastal plain, create a distinct climatic environment by separating the cool, stable air over the Pacific from the much drier atmosphere of the Santa Ynez Valley. This topography leads to unique regional wind patterns, including the Sundowner winds, which occur along the southern slopes of the SYM. Leila Carvalho, Professor of Geography and a researcher at the Earth Research Institute at UC Santa Barbara, studies regional and large-scale climate variability and change, including monsoon dynamics, tropical-extratropical interactions, extreme precipitation and temperature events, mountain weather and climate, and regional modeling. Series: "GRIT Talks" [Science] [Show ID: 41039]

Stanley Chodorow, Emeritus Professor of History at UC San Diego, traces the evolution of food preservation, preparation, and production from ancient times to the modern era. He explores early methods such as drying, salting, and ice cellars, advances like iceboxes, refrigeration, and flash freezing, and innovations in cooking technology from open fires to gas and electric stoves. Chodorow examines the domestication of animals, the development of agriculture, and transformative tools like the wheeled plow and horse harness. He highlights the rise of industrialized food, refrigerated transport, and global trade in products such as sugar, chocolate, and processed foods. Concluding with the health impacts of dietary changes since the shift from hunter-gatherer to agricultural societies, he offers a sweeping view of how technology has shaped what—and how—we eat. Series: "Osher UC San Diego Distinguished Lecture Series" [Health and Medicine] [Science] [Show ID: 40966]

UC Davis is a powerhouse for breakthroughs and impact. Our interdisciplinary research plays a vital role in building the region’s economy. Our research improves the quality of life of residents and contributes to America’s global leadership in technology and innovation. Through collaboration between our top-ranked hospital and veterinary school, as well as our science and engineering discoveries, our research directly improves American lives. Series: "UC Davis News" [Science] [Show ID: 41053]

Sean Morrison, Ph.D., from the Children’s Medical Center Research Institute at UT Southwestern, investigates how stem cells function, regenerate, and interact with their surrounding environment in the bone marrow. His research reveals how leptin receptor-positive cells—key components of the bone marrow niche—regulate hematopoietic stem cell maintenance and regeneration, influence platelet production, and respond to physiological stress like pregnancy. Morrison uncovers a reciprocal relationship between these niche cells and peripheral nerves, showing that disrupting nerve signals impairs bone marrow recovery after chemotherapy or radiation. His work also links retrotransposon activation during pregnancy to increased red blood cell production, with implications for maternal health and transplant medicine. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40449]

Deepak Srivastava, MD, explores how cellular reprogramming offers new hope for treating heart disease. He highlights innovative strategies to regenerate damaged heart tissue by stimulating adult cardiomyocytes to divide and converting fibroblasts into heart-like cells. His team develops a nonviral delivery system using lipid nanoparticles and investigates the role of specific gene regulators in restoring heart function in animal models. Srivastava also discusses a potential oral therapy for aortic valve disease, driven by insights into cellular fate changes caused by NOTCH1 mutations and telomere shortening. Additionally, he reveals how trisomy 21 may trigger congenital heart defects by altering the identity of specialized heart cells. Through pioneering research in genetics and regenerative medicine, Srivastava demonstrates how understanding developmental biology can lead to transformative clinical advances. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40447]

Considered the godfather of A.I. music, UC Santa Cruz professor and composer David Cope, who died in May, 2025, developed the computer program EMI, or Experiments in Musical Intelligence, in the 1980s. It was one of the earliest computer algorithms used to generate classical music. This documentary film by UC Santa Cruz's Bob Giges looks at the impact of Cope's genius on the world of music. Series: "Arts Channel " [Science] [Arts and Music] [Show ID: 40968]

Asteroids, often called “fossils of the solar system,” are remnants from its formation that offer clues about planetary origins and the potential beginnings of life. Dr. Neil Farber, Solar System Ambassador for NASA’s Jet Propulsion Laboratory, explains that some, known as near-Earth objects, pose impact risks—though large, dangerous collisions are rare—and NASA’s Near-Earth Object Surveyor mission aims to detect and track them to inform planetary defense strategies. Asteroids may also hold resources, such as metals or water, that could one day support space exploration, though current technology limits mining feasibility. Recent missions like OSIRIS-REx, Lucy, and Psyche are expanding our understanding of asteroid composition, history, and diversity, with findings including evidence of past water, amino acids, and nucleotide bases—key building blocks of life—raising intriguing questions about whether asteroids helped seed life on Earth. Series: "Osher UC San Diego Distinguished Lecture Series" [Science] [Show ID: 40964]

Chef-turned-chemist Vayu Hill-Maini has a passion: to turn food waste into culinary treats using a fungus called Neurospora intermedia. Visit the postdoctoral researcher in the lab and in the kitchen to learn how this mold could make our food system more sustainable and delicious. Series: "UC Berkeley News" [Science] [Show ID: 40983]

Hear about cutting-edge advances in regenerative medicine, from lab breakthroughs to patient impact. Catriona Jamieson, MD, PhD, introduces efforts at the Sanford Stem Cell Institute to develop therapies that enhance the body’s ability to heal itself. Dan Kaufman, MD, PhD, shares progress in cancer immunotherapy using engineered natural killer cells derived from pluripotent stem cells. Karen Christman, PhD, explains how her team creates injectable hydrogels from pig heart tissue to support heart repair and regeneration after a heart attack. Tiffani Manolis highlights industry support for making cell and gene therapies more accessible. Patient advocate Justin Graves describes his life-changing experience receiving a stem cell-based therapy for epilepsy, underscoring the real-world promise of these innovations. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40705]

AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]

Science communication expert Lisa Warshaw and scientist Rob Signer, Ph.D., offer a practical guide to turning complex research into clear, memorable stories. They explain why strong openings, simple messages, vivid analogies, and visual storytelling are essential to making science resonate. The talk includes tips on avoiding jargon, using soundbites effectively, and preparing for high-stakes moments like media interviews and conference Q&As. Warshaw draws on her experience in global biotech and healthcare communications, while Signer shares real-world lessons from academic science and public engagement. Together, they highlight how clarity and creativity can elevate a researcher’s voice, build trust with diverse audiences, and drive impact across fields. The session is filled with actionable insights for scientists aiming to connect their work with the world. Series: "Stem Cell Channel" [Humanities] [Science] [Show ID: 40460]

UCLA’s Avishek Adhikari, PhD, presents new research on the role of GABAergic neurons in the brain’s periaqueductal gray (PAG) region. Previously studied for their involvement in fear and defensive behaviors, these neurons were found to promote food-seeking behavior when activated—even in fully fed mice. Using calcium imaging and optogenetics, Adhikari’s team discovered that these neurons are active during food approach but suppressed during eating. The effect is stronger for high-value foods like chocolate or crickets and depends on the mouse’s prior experience with that food. A key finding is that these neurons influence behavior through a specific projection to the zona incerta, a subthalamic region. Rather than signaling hunger, this pathway appears to drive food seeking based on reward value, highlighting a new motivational circuit in the brain. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40444]

The land we now call Scripps Oceanography has been home to the Kumeyaay people for thousands of years. A history of encroachment, colonization and displacement from coastal lands has challenged Kumeyaay ocean traditions and practices. Today, Kumeyaay-Iipay-Tipay people are actively revitalizing Indigenous ocean culture. As part of Perspectives on Ocean Science Lecture Series, Stan Rodriguez and Priscilla Ortiz Sawah of the Iipay Nation of Santa Ysabel, and Andrew James Pittman of the Los Coyotes Band and Cupeño Indians, talk about the history of the Kumeyaay culture in the region. Through community efforts, they are rebuilding traditional ha kwaiyo (tule boats), harvesting ha shupill (grunion) and teaching language about the ocean (ha silowik). These intergenerational practices embody Indigenous resilience, resistance and revival — nurturing and evolving Indigenous ocean knowledge, culture and traditions. Series: "Jeffrey B. Graham Perspectives on Ocean Science Lecture Series" [Humanities] [Science] [Show ID: 40596]

It's time for a new narrative for the ocean, one that reflects current scientific knowledge and acknowledges innovative new partnerships and solutions that center the ocean in our future. In this program, Jane Lubchenco, Professor of Marine Biology at Oregon State University and with expertise in the ocean, climate change, and interactions between the environment and human well-being, talks about the two current dominant narratives for the ocean are anchored in the past. The older one considers the ocean to be so vast, bountiful, and resilient that it is simply too big to fail. This first narrative drives pollution and over-exploitation of resources. A second, more recent narrative is that the ocean is now so depleted, polluted, and disrupted, and the drivers of those outcomes are so powerful and complex, that the ocean is simply too big to fix. A third, new narrative is emerging, based on scientific findings, existing solutions, and innovative partnerships and policies. This new narrative acknowledges that the ocean is central to a safe, clean, healthy, just, and prosperous future. This new narrative tells us that the ocean is neither too big to fail, nor is it too big to fix. But it is too important and too central to our future to ignore. Series: "UC Berkeley Graduate Lectures" [Public Affairs] [Science] [Show ID: 40427]

Three major global challenges – climate change, loss of biodiversity and its benefits, and inequality and inequity among people – are typically tackled within three separate silos. However, scientific knowledge tells us that the three are inextricably linked. If the problems are not considered together, solutions to one may undermine solutions to the others. Moreover, more holistic, integrated solutions can deliver multiple co-benefits. Success requires integrated solutions. Jane Lubchenco, Professor of Marine Biology at Oregon State University, talks about the historically ambitious, innovative policies implemented by the Biden-Harris Administration to achieve this integration. Lubchenco is a marine ecologist with expertise in the ocean, climate change, and interactions between the environment and human well-being. From 2021-2025, she served as Deputy Director for Climate and Environment in the White House Office of Science and Technology Policy. Series: "UC Berkeley Graduate Lectures" [Public Affairs] [Science] [Show ID: 40426]

The human body has traits that evolved at different times, from 1.5 billion to 2 million years ago, each bringing health benefits and risks. Multicellularity enabled organs and cancer. The immune system defends us but can cause inflammation. Breastfeeding supports infant health but relates to breast cancer risk. Menstruation and invasive placentas improved reproduction but led to pain and cancer risks. Human-specific traits like bipedalism and aging brought new issues like back pain and childbirth problems. Hair loss and sweat glands helped us stay cool but increased skin cancer risk. Our hunter-gatherer past shaped our microbiome and health, but also made us prone to modern diseases from lifestyle changes. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40702]