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The Human Upgrade with Dave Asprey
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The Human Upgrade with Dave Asprey

Author: Dave Asprey

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For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own performance and embrace possibility with The Human Upgrade™.

You’ll meet bright thinkers and radical doers who push the boundaries of science, technology, personal development, and human performance in every way imaginable. You’ll learn from experts around the world who elevate what it means to be human.

Every guest you listen to, every topic you learn about, every new idea you discover on this podcast moves you forward.

Join The Human Upgrade™ with Dave Asprey on this next evolution to upgrade your mind, body and life. 

1143 Episodes
Who doesn’t want more radiant skin? Not only is our skin our largest organ, but it influences our confidence and how we connect with others. That’s why I'm excited to be sitting down at my Austin, Texas studio with skin expert and longtime friend, Rachel Varga. Rachel is a double board-certified aesthetic nurse specialist, having performed over 20,000 procedures since 2011. She was one of the first to combine functional slow-aging techniques, biohacking, and modern medical aesthetics—teaching us how to tune in to what our skin is telling us about our internal health and what to do about it. Not only has she had a significant impact on the world of skin science, but she's also trained countless doctors, nurses, and their teams on the art of aesthetics.I can personally vouch for Rachel's expertise as she's worked on my skin, enhancing it with innovative techniques involving lights and other intriguing procedures. But today, it's not just about aesthetics or vanity. We dive deep into the health of our skin, specifically discussing how to reduce oxidative stress and implement purification and detoxification techniques to become radiant from the inside out. With Rachel's unique insights you don't typically hear in the skincare space, you'll learn secrets to having not just younger-looking skin, but more pure energetics. What you’ll find is that healthy skin is not just about putting some crap on top of it, it's about nourishing your skin from the inside, doing the energetic practices of biohacking, and then using vetted products that actually work and are safe. If you're hungry for more, Rachel helps inspire others with her unique strategies to slow cellular aging and enhance radiance at and has previously graced us with her wisdom on of this podcast (#668). I also highly recommend checking out her recent paper on Oxidative Stress Status and Its Relationship to Skin Aging. And, be on the lookout for her upcoming book, Radiance: The New Skin Science.(02:11) Combatting Modern Stressors: From Oxidative Stress Status to EMFs• The harm oxidative stress from the environment can cause on your skin• How often you should be washing your face• Benefits of EMF-blocking clothing • EMFs in modern vehicles• How EMFs affect the skin and ways to combat it• How your skin impacts your confidence and ability to connect with others• Acknowledging the impact of lookism• Signs of oxidative stress status (22:02) Conscious Skincare: Navigating Toxins, Purification Processes & Eye Health • Find clean skincare vetted by Rachel:• Hidden toxins to look out for in “clean” skincare products • the importance of being a conscious consumer of products that touch your skin • The role of purification in keeping skin clean and protected • How to biohack your home to support your skin health• Purifying your home environment to reduce oxidative stress• What’s causing ocular diseases and aging of the eyes• How to protect your eyes as you sleep(37:53) Unlocking Radiance: Biohacking, Detoxing & The Secrets to Energetic Beauty• Detoxing as a part of radiance• Biohacking Conference:• The difference between men and women when it comes to radiance and detoxing• The best type of candles to use in your home• Discerning who has truly radiant energy• Understanding the four brains • What happens to your skin when dealing with negative energy (narcissism, stress, toxins)• Benefits of biohacking on your physical and mental stateResources:Use code DAVE and save 15% sitewide at FREE Biohacking For Ageless Beauty Training! Book a One on One with Rachel Varga for customized skin care, rejuvenation guidance and ongoing support! Join SkinCamp for expert Tutorials on skin care, make up, hair care (and growth), biohacking, and more! Join The School of Radiance Membership for cultivating resilient radiance through practices and mentorship: to The School of Radiance Podcast: @rachelvargaofficial on all platforms (except twitter)Podcast: Face Aging with the Science of Beauty – Rachel Varga #668EMF Resources: Oxidative Stress Status and Its Relationship to Skin AgingDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: The Human Upgrade is produced by Crate Media.See Privacy Policy at and California Privacy Notice at
In today's episode, we're joined by Dr. Gad Saad, a professor of marketing at Concordia University's John Molson School of Business. More significantly, Dr. Saad has spent a decade as the research chair in evolutionary behavioral sciences and Darwinian consumption.Beyond his extensive research and academic accolades, Dr. Saad reaches out to a broader audience, sharing his insights through his popular blog, YouTube channel, and podcast. As someone deeply interested in challenging harmful ideologies, I've taken note of his impactful book, The Parasitic Mind. Today, I'm particularly eager to delve into the findings of his latest release, The Saad Truth About Happiness.In our discussion centered around his newest book, we delve into the evolutionary aspects of happiness. As someone who's written extensively on longevity and aims to live to at least 180, I believe in the importance of happiness as a skill. With Dr. Saad, we explore living the life you truly desire, the role of anti-fragility in happiness, and the inherent biological differences in male and female behaviors. It's crucial, especially in today's climate, to understand the triggers that may be rooted in our biology or false belief systems. Drawing from personal experiences, I can vouch for the invaluable insights in Dr. Saad's book. Listeners, it's a must-read for those keen on understanding and cultivating happiness.(03:50) Decision-Making in Relationships & Academia• Must-have ingredients for happiness• The impact of your relationship on happiness• When do you make the decision to decouple from a relationship?• How statistical decision theory applies to academia• Read: The Parasitic Mind by Dr. Gad Saad • The garage band effect that occurs in academia that prevents action-taking• Why academics who go on the Joe Rogan Experience are ridiculed by peers• Read: The Laws of Human Nature by Robert Greene• Behind the scenes of our interviews on Joe Rogan’s podcast• Joe Rogan Experience #275 - Dave Asprey• Joe Rogan Experience # 2012 - Dr. Gad Saad• Happiness in moderation vs. living high on life(19:40) Perfectionism, Criticism & The Genetics of Happiness• Navigating the inverted U curve for perfectionism• Handling the two groups of critics• The Science Behind Just One Mold Toxin in your Coffee by Dave Asprey• The genetics of happiness • Applying the psychometric scale of internal vs. external locus of control to happiness• How our evolutionary behaviors can become maladaptive in modern society• Exploring how having children impacts happiness • What the research shows about how to choose a long term partner (47:10) Evolutionary Insights on Mating, Cheating & Play• The evolutionary roots of sexual variety seeking • Why certain cultures tolerate women on the side more than other cultures • The impact of birth control and hormonal changes on fertility and attraction• Read: The Mating Mind by Geoffrey Miller• The link between the ovulatory cycle and women's beautification• What increases men’s testosterone: a study providing context for the mid-life crisis• Why play is essential for happiness • The re-education of Jordan Peterson• Read: The Saad Truth About Happiness by Dr. Gad SaadResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: Website: gadsaad.comRead: The Parasitic Mind by Dr. Gad SaadRead: The Saad Truth About Happiness by Dr. Gad SaadX: @GadSaadPodcast: The Saad TruthYouTube: @doctorgadsaadFacebook: Human Upgrade is produced by Crate Media.See Privacy Policy at and California Privacy Notice at
Today, we welcome back a guest from the early days of this podcast, fellow former vegan and esteemed researcher and scientist, Chris Masterjohn. Chris Masterjohn earned his PhD in Nutritional Sciences from the University of Connecticut, and has worked as a postdoctoral research associate and Assistant Professor of Health and Nutrition Sciences. In 2016, he transitioned to entrepreneurship. These days, Chris conducts independent research, consults, develops information products, and creates free content to help people improve their health. Chris is dedicated to sharing practical principles from complex science, and to the pursuit of truth and continuous learning. He's a biohacker from before the word “biohacking” came to be, appearing on episode 16 of this podcast when I was just getting that movement started, because he not only pays attention to how stuff works in the world and academic research, but he hacks his own body. I've always liked the way he thinks mechanistically about biology, nutrients, and what to eat. In this conversation, we talk about how to recover from veganism and reverse the effects of oxalates, highlighting the long term health impacts of the vegan diet. His own self experimentation lately is of particular interest to me as he’s been exploring the intersection of genetics and mitochondrial health to heal niche health conditions and even quell extreme fears or stressors.We also talk about the link between energy metabolism and psychological trauma, chronic pain and oxalate overload, and even explore the potential dangers of methylene blue from his latest 58 page research paper breaking down the importance of correct dosing. If you’re a true biohacker, you’re going to love this deep dive into how minerals and metabolism play a huge role in our biology.(03:47) Genetic Optimization: A New Approach to Healing Chronic Pain & Disease• How his perspective on nutrition has changed since our first episode• The extreme effects veganism had on his health• Using genetics research to find solutions to rare health issues• The role of AI in diagnosing health conditions—now and in the future• Focusing on mitochondria as the root cause to heal health issues • Access his program:• What will reverse the anti fertility trend?• The psychological rewiring required to heal chronic disease states • Lowering your stress response with GABA and hierarchical exposure therapy• How energy metabolism and psychological trauma symptoms are related(32:08) Recovering from Veganism & Oxalate Overload• Can you do veganism well?• Addressing the impact of plant toxins and oxalates• The link between chronic pain and oxalate overload• How to reverse the effects of oxalates• The use of biotin to clear oxalates and dosing suggestions• Read: Toxic Superfoods by Sally Norton • Oxalate dumping symptoms explained • Advice for recovering vegans• Read: Le Chatelier's principle• Viome: Methylene Blue: Potential Dangers & Dosage Recommendations• The dangers of combining methylene blue with ayahuasca and psychedelics• Research conclusions on methylene blue dosing• How methylene blue can impact people with Alzheimer’s• Side effects of combining methylene blue with SSRIs• Using methylene blue to help allergy sufferers• ED as a side effect of methylene blueResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: Website: chrismasterjohnphd.comFacebook: Everything You Need To Know About Saturated Fat & Cholesterol with Chris Masterjohn #16Podcast: Nicotine, the Perfect Psychotropic? Dr. Paul Newhouse # 494The Human Upgrade is produced by Crate Media.See Privacy Policy at and California Privacy Notice at
If you struggle with retaining sharp focus or have been diagnosed with ADHD or other conditions that impede your brain from functioning at its optimal level, this is the podcast episode for you. We learn about a (literally) out-of-the-box solution to attention training—video games. Yes, you read that right.Our guest today, Dr. Adam Gazzaley, holds an M.D. and Ph.D. in Neuroscience from Mount Sinai School of Medicine and completed Neurology residency at the University of Pennsylvania, followed by postdoctoral training in cognitive neuroscience at UC Berkeley. He's currently the David Dolby Distinguished Professor at UC San Francisco and the Founder/Executive Director of Neuroscape, a center focusing on technology-driven scientific research. So it’s safe to say that Adam is not your prototypical basement gamer.As someone who struggled with focus and attention due to Asperger’s syndrome and brain fog due to the effects of toxic mold exposure, figuring out how to retrain my brain to be able to retain more information and focus longer was one of the first areas of biohacking I ever explored. This is why I’m so excited to be talking all about Endeavor Rx today, the world's first FDA-authorized prescription video game treatment for pediatric ADHD—and Endeavor OTC, for adults who struggle with ADHD, focus, attention, and distraction.We explore how we can measure attention and improvement in focus, the biological systems that control what we focus on consciously and subconsciously, the role of nutrition in our ability to focus, the underlying technology of Endeavor, measuring its effectiveness, and Adam’s vision for how we can use biosensing technology—now and in the future—to optimize awareness, focus, mood, and more. (03:07) Addressing Modern Attention Challenges• Defining our attention systems and how to measure them• How I learned how to pay attention, even with ADHD• Read: The Distracted Mind by Adam Gazzaley and Larry D. Rosen• Tools we have for addressing attention challenges• What I use now for brain function and focus• The role nutrition plays in being able to focus• What typical of video games can aid in training attention • The potential negative effects of shooter games (20:37) Understanding Endeavor: How to Train Attention Using a Video Game• Top down vs. bottom up thinking• Endeavor: the video game that trains your attention• The journey of getting Endeavor approved by the FDA• The effectiveness of Endeavor for adults• What to expect from playing Endeavor• How you can utilize multimodal biosensing for quantifying physiology• Hugs from Dr. Love with Paul Zak – #334• Exploring what technology is used in a sensory immersion lab, including AI(49:21) Exploring Potential Costs & Opportunities of Biosensing Technology• Understanding the potential adverse effects or downsides of this technology• Join the Live Audience:• The exhaustion factor in playing Endeavor• What video games would be likely to reduce cognitive function• Using Lion’s Mane for increasing brain function• What this system could look like in 10 years ResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: Endeavor OTC: Human Upgrade is produced by Crate Media.See Privacy Policy at and California Privacy Notice at
I am a sucker for supplements with extensive and impressive research to prove their biohacking benefits, and OMNi-BiOTiC is one of them. Research studies by OMNi-BiOTiC show a 50% or 70% improvement in things like brain function, insulin sensitivity, and detoxification which is really compelling—and exactly why we have Hannah Kleinfield on the show today.Hannah Kleinfeld is the Chief Operating Officer of Allergosan USA, the U.S. joint-venture partner of Institut Allergosan, a global leader in microbiome science and gut health products. She is dedicated to educating about the importance of gut health as a foundation for wellbeing and passionate about helping others experience healthy and vibrant lives. That passion is clear in today’s episode where she shares the research and broad-ranging benefits of the OMNi-BiOTiC line of probiotic supplements. We talk about why it’s so important to have a thriving gut, the important link between gut health and brain function, what is most likely to harm our guts, especially in the US, and how to find which probiotic is right for you. If you're into biohacking, whether you're already doing really well and you're looking for what's next, or you've still got that extra 20 pounds that won't budge but you can see you're moving in the right direction, this might be a really big step to help move you toward your goals. If you’d like to try these products for yourself, go to and use code DAVE20 to get 20% off.(02:24) Revitalizing Gut Health with New Technology• Repairing her gut after Lyme disease• The difference between European and US-based supplement brands• Shop OMNi-BiOTiC (use code DAVE20 to get 20% off)• Where to start with probiotics• What is most harmful to the gut(19:25) Probiotic Power: Detoxing, Brain Boosting & Insulin Resistance• How to address a bad bacteria—Clostridium difficile• How a probiotic can change your brain activity• Delivery method of OMNi-BiOTiC• Exploring the benefits of OMNi-BiOTiC Hetox for liver support and insulin resistance• Recommended tests for monitoring what’s going on in your body(34:41) All You Need to Know About Probiotics • Why OMNi-BiOTiC doesn’t use spores• Pairing OMNi-BiOTiC with other probiotics• What people should know about probiotics• Tips for clearing SIBO• When to take probiotics after being on antibiotics ResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: Website: (use code DAVE20 to get 20% off)Instagram: @omnibioticlifeThe Human Upgrade is produced by Crate Media.See Privacy Policy at and California Privacy Notice at
Today's episode is with my friend Susan Bratton, who is an intimacy expert with 20 years of experience. She runs a publishing company called Better Lover, and has a supplement company called The 20. Her expertise is in ageless sexuality, sexual biohacking, libido supplementation, and sexual regenerative therapies that roll back the clock on aging.Whether you're a man or a woman, you’ll learn the specific things you can do to change the performance, the shape, the sensitivity, and the longevity of this amazing part of your body. All life on earth—human and otherwise—runs through the same set of automated decision making that happens before your brain even gets engaged, one of which is what we’ll be talking about today, which keeps the species alive forever. Let’s call it fertility. It is actually a source of nourishment for us. So when you're of the appropriate age, this is as important as eating, breathing and drinking water. Yet, we pay more attention to our food than we do to our reproductive and recreational sides of staying connected to our humanness. That's why Susan's on the show today. She shares the science behind the link between intimacy and longevity, explains how to prevent atrophy in these important areas of our bodies, dispels myths about self-pleasure, gives a tutorial on all kinds of toys that can increase function and pleasure for all genders, and lists tips for creating more connection and communication in the bedroom. If you want to check out any of the toys or guides mentioned in this episode, go to (03:14) How to Live Longer by Engaging in More Intimacy• Honoring sexual expression outside of the gender binary• The Human Awareness Institute:• How to regenerate and enhance your sex life• Interesting insight on semen retention• The correlation between regular intimacy and lifespan • Categories of pleasure toys for men and women • The benefits of vacuum erection devices and how to use them • Sexual enhancement products and guides: Orgasmic Cross Training: Toys & Supplements to Expand Pleasure Potential• Natural nitric oxide supplements that help reverse atrophy• How Nitric Oxide Controls Oxygen & Nutrient Delivery, Aging & Quality of Life - Nathan Bryan, Ph.D. / Pneuma Nitric Oxide #1041• Regenerative stack for male and female enhancement• How to fix atrophy and focus on engorgement in female reproductive parts• Orgasmic cross training: 8 different toys for females• How often a man or woman should self-pleasure in order to maintain their potency• The different types of vibrators and their uses(42:02) The Power of Safe & Proper Touch for Female Pleasure • Orgasmic cross training: 4 different toys for males• Understanding the vulval activation and sensory pleasure women need prior to penetration• Why yoni massages can be so powerful• The effects of shame and lack of proper touch in receiving pleasure for women• The bullseye touch technique:• Sex Life Bucket List: moredave.comResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: More Dave: moredave.comWebsite: susanbratton.comInstagram: @susanbrattonFacebook: Susan BrattonX: @susanbrattonLinkedin: Susan BrattonBlog: betterlover.comSex Life Bucket List: moredave.comThe Human Upgrade is produced by Crate Media.See Privacy Policy at and California Privacy Notice at
So much of your reality is determined by your brain, and if you have dealt with chronic disease or mental health struggles like me, it can feel like there’s something wrong with you. But, it’s probably not you. It’s probably a brain problem. Today’s guest, Dr. Brandon Crawford, is here to provide some hope and some answers. Dr. Brandon Crawford is a board-certified Developmental Functional Neurologist, driven by training from esteemed minds in chiropractic, functional neurology, and functional endocrinology. Renowned as a laser expert, Dr. Crawford shares groundbreaking laser and light therapy protocols in lectures around the world, revolutionizing treatments for various conditions through photobiomodulation. He has achieved absolutely incredible results helping people rewire their brains and heal chronic conditions at the NeuroSolution Center of Austin. In this conversation, we dive into the really cool technology and research he uses to do it – and share things you can do at home to improve your own brain health. You’ll learn how to hack your brain with light, get an intro to light hygiene, and be educated on the ways we derive energy from light. We also cover indications of a healthy brain and how to continuously promote brain health, why talk therapy may not be the best way to heal trauma, immediate solutions for when you’re feeling activated by fear, and share advice for parents with kids struggling neurologically after the pandemic mask mandates.(02:36) Optimizing Your Brain With the Right Light• Blue light’s impact on brain tissue• How to combat light toxicity with red light exposure• TrueLight Luminaire:• How OCD can be a superpower• Why lasers are used in the NeuroSolution ESM methodology• Read: The Fourth Phase of Water by Gerald Pollack• A discussion on how we derive energy from light• Practices for getting more sunlight without causing skin harm• How you can hack your brain with light• TrueDark glasses:• 40 years of Zen: Tools to Measure Neurological Health & Heal the Vagus Nerve• Leveraging beam physics to heal chronic health conditions combining light and frequency• What to expect from a consultation at NeuroSolution Austin:• How balance indicates neurological health• Is coffee good or bad for the brain?• Danger Coffee:• Why cognitive behavioral therapy may not be as useful as laser therapy• The science behind healing trauma through vagus nerve stimulation• The Birth of LSD with Dr. Stanislav Grof, Father of Transpersonal Psychology #428(44:21) How to Manage Triggers & Support Kids’ Neurological Development • How to stop a panic attack or fear paralysis state using breathwork • How we’ve reinforced ancient practices through science• Vagal nerve hacks for frustration and anger• What stimulating the cymba concha can do for your vagus nerve• How masks have inhibited childrens’ abilities for facial recognition and social engagement• How to restore neurological damage in kids that have occurred over the last 3 years• Things parents can do at home to help kids affected by mask mandatesResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: NeuroSolution Austin: neurosolutionatx.comWebsite: neuro-solution.comInstagram: @neuro_solutionsTruedark: Truedark.comThe Human Upgrade is produced by Crate Media.See Privacy Policy at and California Privacy Notice at
If you're frustrated with a system prioritizing profit over societal well-being, this episode is pivotal. Today, we dive deep with Ivor Cummins, a Dublin-based biochemical engineer with a knack for simplifying complex topics. Based on his personal history of insulin resistance and health struggles, he was able to self-heal through nutrition and a low carb diet. In this conversation, we examine the nexus of insulin resistance, heart health, and the current medical system’s failure to diagnose and treat metabolic diseases.Our discussion sheds light on the origins of our current societal framework and its influence on our health and choices. Ivor's unique perspective, combining the understanding of intricate systems in both power and biology, illustrates a clear parallel: We’ve been given systems that aren’t working for the greater good. In many cases, our health is in our own hands. Mine and Ivor’s stories of weight loss are two of millions examples of that. However, recognizing these facts offers hope, because when you’re informed and aware, you have the freedom to choose what’s right for you, and the confidence to stand up for it. With that goal in mind, we examine the impact of influential figures like the Rockefellers and J.P. Morgan, discuss what’s going on at the WHO in response to the recent COVID pandemic, and explain the need for distributed versus central governing systems, among many other blockades to true freedom we’re currently facing. Expanding our collective awareness through these conversations is the key to reclaiming control over our lives. Lastly, I can’t emphasize enough the power of consumer choice. Institutions can't dictate our spending without offering value. There's a peaceful, two-fold solution to our current dilemma— leveraging technology and altering our behaviors. But most importantly, dispelling the pervasive myths that have clouded our understanding and judgment for decades. (03:22) Ivor’s Journey: Healing Insulin Resistance with a Low Carb Diet• The metaphor behind The Fat Emperor• Test results and research that encouraged Ivor to change his eating habits• What Ivor experienced through trying a low carb diet• How to get your appetite and cravings under control with proper nutrition• The science behind insulin vs. cholesterol• What’s missing in medical training to properly diagnose and heal metabolic syndrome?(24:27) America’s Monopolist Legacy: Shaping Health & Political Systems• Addressing the implications of the new WHO treaty’s verbiage and requirements• Explaining the Pandemic Business Model• The history of the Rockefeller Foundation & United Nations trilateral commission• Dr. Jakob Nordingaard's Interview• J.P. Morgan’s influence on society• The cultural impacts of monopolists’ agendas and propaganda(37:44) The CBDC Threat, Power Dynamics & Achieving Cognitive Freedom• Hidden dangers of the Central Bank Digital Currency• The importance of having a distributed power model vs. central model• What we can do to create positive change in a corrupt system• How to achieve cognitive freedomResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: Fat Emperor Podcast: metabolicduo.comYouTube: @IvorCumminsScienceX: @FatEmperorThe Human Upgrade is produced by Crate Media.See Privacy Policy at and California Privacy Notice at
You've heard lots on this show about biohacking, longevity, and how to help your brain and body perform better. But what if you could do the same things for your pet? I've spent most of my life with pets and/or farm animals so I’m thrilled to have my longtime friend, Dr. Gary Richter, America's favorite veterinarian, here to tell you all you need to know about biohacking for your pets.Dr. Gary Richter, DVM, is a distinguished veterinarian, international bestselling author of The Ultimate Pet Health Guide, and founder of Ultimate Pet Nutrition. He’s also the author of two new books, Longevity for Dogs and Longevity for Cats. Dr. Richter is certified in veterinary acupuncture, as well as veterinary chiropractic, understanding the benefits of both conventional and holistic treatment methods. He also places great emphasis on the well-being of the pet owner, knowing that a sick pet can cause great strain on a person's life.Today, we talk about what supplements your pet should be consuming, how you can regenerate their health, genetic testing for pets, what's coming in the future, the things a lot of people believe about pet diets that are absolutely not true, and a bunch of other stuff from a top expert in the field. All the studies show that having a pet raises your oxytocin. It makes you live longer. It increases heart rate variability. It makes your kids have healthier gut biomes, on and on. Tune in to start learning how to support your pets as well as they support you.00:03:00 — How Long Can Our Pets Really Live?• The truth about vegan cat food • How long cats and dogs can live• Why biohacking pets may be easier than for humans• Why dogs like cat poop• The oldest animals he’s worked with • Physiological differences between dogs and humans • How much it costs to invest in your pet’s longevity• Pillars of aging for pets • The root of genomic instability and suggested solutions 00:16:22 — Nutritional Support & Preventative Care for Pets• What to feed your pets for optimal health• Easy and readily available supplements for your pets• Upgrade Labs:• Dave’s experience with electroacupuncture for his dachshund• Documentary:• Testing you can do for your pet to find out predispositions• How much Vitamin D you need in your pet food00:39:41 — Top Supplements to Support Your Pet’s Optimal Health• Can you and your pet take the same supplements?• What a whole food diet looks like for pets• Benefits of MCT oil for dogs and cats• Read: The Ultimate Pet Health Guide by Dr. Gary Richter• Recommendations for how many supplements your pet needs• Racehorse biohacking• Dr. Richter's supplement list for dog/cat longevity • Read: Longevity for Dogs by Dr. Gary Richter• Read: Longevity for Cats by Dr. Gary Richter• Integrative Veterinary Medicine:• (Use promo code ULTIMATEHEALTH40 for 40% off)ResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: Pet Nutrition: (Use promo code ULTIMATEHEALTH40 for 40% off)Free Resource: Dr. Richter's supplement list for dog/cat longevity Read: The Ultimate Pet Health Guide by Dr. Gary RichterRead: Longevity for Dogs & Longevity for Cats by Dr. Gary RichterRead: The Ultimate Pet Health Guide by Dr. Gary RichterIntegrative Veterinary Medicine: ahvma.orgWebsite: drgaryrichter.comThe Human Upgrade is produced by Crate Media.See Privacy Policy at and California Privacy Notice at
Our guest is Jack Dell’Accio, the CEO of Essentia. Essentia has been working on non toxic, organic mattresses for 20 years. Of most importance to Jack is the impact of restorative sleep in terms of recovery from disease, prevention of disease, longevity, and performance. He's funded a bunch of research on sleep quality and has worked directly with health gurus including myself, professional athletes, various teams in the NBA, NFL, MLS, and over 25% of active NHL players on creating healthy sleep performance. Essentia’s organic mattress has been recognized by several internationally renowned organizations including the Mayo Clinic’s Well Living Lab, and has been named the #1 foam mattress by Consumer Reports for seven consecutive years. If you're a long time listener or you've read some of my books, you understand how getting a lot of sleep is probably not good for you. If it's more than eight hours, your chances of dying are higher than people who get seven hours a night. The reason I wanted to have Jack on the show today is to go over the latest data on how sleeping on an organic Essentia mattress can improve REM and deep sleep by between 20 and 60 percent. Remember—it's not the volume, it's the quality of sleep that matters. Jack provides actionable data on how to improve the quality of your sleep through ensuring your mattress is supporting you from a biological standpoint, so you can make every minute count. We explore what the organic Essentia mattress is made of and the technology that sets it apart from others on the market. We also share our tips for getting the best quality sleep you can get, and how getting regular deep sleep impacts all other areas of your life.00:02:35 — How Non-Toxic Essentia Mattresses Support Sleep on a Chemical Level• Why athletes aren’t able to sleep well• The number 1 thing impacting your sleep quality • Environmental toxins’ impact on brain metabolism• Why comfort might not be the most important factor in your mattress• Shop:• How Essentia prevents mold in mattresses• Why putting quartz in mattresses is beneficial for blood cell performance• Exploring the science behind quantum effects00:26:34 — Unraveling Sleep Secrets: Longevity, Light & Legislation• Measuring heart rate variability to determine quality of sleep• How long the people who live the longest sleep • True Dark:• The implications of the government’s ban on all incandescent light bulbs• Why there’s legislation around what mattresses are made of• The resistance Jack received from chemists in removing chemicals from mattresses• How a decrease in sleep quality can accelerate the rate of aging • The Bulletproof Diet: — Biohacking Rule #1: Prioritize Quality Sleep• The importance of rest for recovery and performance• Sleep:• Mattresses for women versus men• Sleep hacks for temperature management• The specs, content and density of the Essentia Mattress• Upgrade Labs:• Biohacking Conference:• How to determine if a company’s marketing claims are real or fake• Exposing marketing over substance in the mattress industry• Mold Documentary:• What Jack is developing to improve people’s wellness through sleepResources:Upgrade your sleep today! Take advantage of Essentia’s Labor Day Sale PLUS use promo code DAVE to get an ADDITIONAL $100 OFF your mattress!Visit to learn more.Dave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: Instagram: @essentiaorganicmattressYouTube: Essentia Organic MattressTikTok: @essentiaorganicmattressJack Dell’Accio: @jackdellaccioThe Human Upgrade is produced by Crate Media.See Privacy Policy at and California Privacy Notice at
The environment you live in has the most profound impact on your health and wellbeing, but are you aware of the toxins and pollutants we’re surrounded by on a daily basis? That is why today’s episode is so important. We talk about toxins that are overlooked in your house and what you can do about them. Our guest is Ryan Blaser, the founder and CEO of Test My Home, an environmental company dedicated to improving your health by changing the environment around you. As a functional medicine doctor for your home, Ryan uses his expertise in building biology and healthy home consulting to identify and address toxic sources that could be impacting your health.After a unique personal wellness journey, Ryan founded Test My Home to help others achieve optimal health. He personally experienced the detrimental effects of mold exposure and lead inhalation, which caused unusual and serious health symptoms like fatigue, weight loss, and brain fog. After unsuccessful attempts with conventional doctors, Ryan took the initiative to investigate his home environment and found the source of his health issues. He cured himself and is now sharing his knowledge and experience with the world.The definition of biohacking is to change the environment around you, and inside of you, so you have full control of your own biology. This is a part of core biohacking, and it's one I think a lot of us just don't think about. We take our supplements, we do our cold plunges, we do all the different biohacks, but just cleaning up the environment around you could make a really big difference. So, in this episode you’ll learn about the most common pollutants and toxins in your home, how to identify them, and ways you can mitigate or eliminate their effects.WE APPRECIATE OUR PARTNERS, CHECK THEM OUT AND GET YOUR DISCOUNT!5 part healthy home mini course: My Home: booking through the website with TMH's sales team, mention Dave Asprey for a discount!Instagram account for lots of free content: — The Top 5 Pollutants Indoors & What To Do About ThemRyan’s personal experience getting sick from environmental toxinsMoldy Movie: moldymovie.comThe myth behind green buildingsSolutions for toxic mold exposure in residential buildingsHow to identify mold in the homeWhat you should do if you have a smelly home instead of air freshenersHow important is a gas stove vs. an electric range?How lighting affects us and types of lights to use in your home00:21:30 — Understanding the Dangers of Fragrances, Mold & VOCsThe surprising ingredients in candles and air freshenersHomebiotic spray: to do when you live in humid environments to prevent moldMeridian Upgrade Labs: for dealing with moisture in your homeRecommendations to mitigate carbon monoxide dangersExplaining VOCs and how you can absorb or filter them out The extreme toxicity and effects of formaldehyde 00:42:11 — Sneaky Pollutants: Protecting Your Home from Gas & NoiseSymptoms of a leaky sewer gasOzone pollution versus ozone therapySneaky places you can find surface radiation from nuclear plantsProtecting yourself from small particles Reducing noise stressors in the homeLearning to listen to your body and intuition to identify toxins or stressorsDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: Moldy Movie: Human Upgrade is produced by Crate Media.See Privacy Policy at and California Privacy Notice at
Alan Graves is the CEO of Do Not Age, a UK-based longevity company, and he’s been fully immersed in the biohacking space since 2019. In that short time, he’s become a leader in supplementation and expanded his curiosities—even as far as outer space.We talk about his preparation for an upcoming Virgin Atlantic flight to the stars, and how he plans to protect his human form in such an environment. We also touch on our dieting journeys—from veganism to all-meat and everything in between, ride the pharmaceutical industry for its ongoing role in promoting sickness in many forms, and sing the praises of Do Not Age’s innovative line of products.From deep space to raspberries, detailed biochemistry to FDA politicization, this episode has it all—as Alan wields an informed and inquisitive perspective on all things biohacking, past, present, and future. 00:01:52 — Going to Space: Preparation, Inspiration & Motivation • Alan’s preparation to go to space with Virgin Atlantic • Looking ahead to a total perspective change • Dave’s family background in aerotech • Sending a coffee bean to the moon (maybe)• Exclusive: Interview with Ketone Expert Dr. Richard Veech #29900:08:14 — Avoiding & Counteracting Antinutrients  • Remembering their vegan experiences• Dave’s current diet and how he got there• The Bulletproof Diet by Dave Asprey• Liam Hemsworth and oxalic acid• Why you shouldn't eat raspberries • Beef vs. chicken vs. fish 00:14:55 — Becoming a Biohacker: How, When & Why?• Realizing longevity can be extended • Translating scientific papers for the layman • Who paid for the paper?• We Can Slow Down Aging Right Now – David Sinclair, Ph.D. #626• Investing with integrity 00:22:49 — Do Not Age (DNA) Products & Innovation• Long term view on research at Do Not Age• Taking the hacker approach to business challenges • Update on NMN’s status in the US• Importance of guaranteed purity • Breaking down Do Not Age’s resveratrol offering• The role of sirtuins in our body• Resveratrol vs. pterostilbene• Singing the praises of Calcium AKG• Prevention is easier than treatment 00:42:33 — What’s Next? Looking Ahead at Longevity• How long do you think you’ll live?• Artificial intelligence is based on the past, not the future• The rise of collagen peptides• Low cost + high efficacy + data proven• Dosing daily collagen tips • Dave takes a visit to Walmart headquarters • Testing for false product claims on Amazon • How and why to buy the good stuff ResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: Do Not Age: donotage.orgInstagram: @do.not.ageFacebook: @DoNotAge.orgX: @Do_Not_AgeThe Human Upgrade is produced by Crate Media.See Privacy Policy at and California Privacy Notice at
Dialing in from Dubai, today, we hear from global inventor and investor, Saba Yussouf, about how to position STEM technologies – science, technology, engineering, and math – to prevent infection, treat water, and even fight 100-year problems like climate change.Half business leader and half scientist, herself, she is a futurist, versed in the fine-tuned details of STEM, and putting it all to work through her disruptive investment record around the world. We learn about nanobubbles and their benefit to the brain, unpack the power of intuition and where it comes from, meet the monstrous homunculus, and so much more.We also highlight Saba’s most recent projects, Invisi Smart and Ficks Labs, tip our caps to groundbreaking research of the past, and look to a brighter (and smarter) future in this forward-thinking conversation. If you need to feel good about where the world is headed, and who might lead us there, this is the episode for you.00:02:06 — Biohacking the Brain: What are Nanobubbles? • TrueDark anti jet lag glasses• Learning about nanobubbles• Efficient oxygen delivery to the bloodstream• This is your brain on oxygen • Research: Healthy fats and exclusion-zone size• What else can be delivered through nanobubbles?00:09:52 — Letting Intuition Be Your Guide  • The marketing vs. engineering innovation death loop • How did Saba Yussouf learn intuition? (Hint: She didn’t)• Why women tend to know the truth• How do you avoid overthinking your intuition?• Galvanic skin response and muscle testing• The brain cells in our stomach • Meeting the homunculus• Science is in your heart, not your brain• What it means to be a scientist 00:24:05 — Realizing the Consciousness of Water • The groundbreaking work of Dr. Masaru Emoto• Why Saba doesn't drink water when processing negative thoughts • Speaking, or singing, positive affirmations to your water• How ice crystals have been shown to react to music00:29:09 — Understanding the Innovation Behind Invisi Smart• An update on titania disinfectant technology • All natural and mineral-based formula • When the world says “no thanks” to disruptor tech• Invisi Smart and pivoting to cleaning up greenhouse gasses• Saving the world one stinky armpit at a time• What is Ficks Labs?• Disruptive deep science meets affordable luxury• The disinformation in modern advertisingResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: Invisi Smart: invisismart.comInstagram: @sabayussoufThe Human Upgrade is produced by Crate Media.See Privacy Policy at and California Privacy Notice at
IN THIS EPISODE OF THE HUMAN UPGRADE™, we revisit a conversation Dave had with Magnus Lygdbäck in Spring of 2022. You’ll learn how a trainer of superheroes and superstars combines core principles of fitness, nutrition, structure and balance.Magnus Lygdbäck, a Swedish health and wellness expert, entrepreneur, and lifestyle coach, joins the show to discuss powering your life in ways that most benefit your health and energy.For more than 20 years, he’s trained some of the world’s most recognizable actors, musicians, athletes, artists, and high-performance business entrepreneurs.Musicians like pop stars Katy Perry, Dua Lipa, Harry Styles and Britney Spears. Actors like Gal Gadot for Wonder Woman 1984; Alicia Vikander, for Tomb Raider; Ben Affleck, for Justice League; and many more.He designed Alexander Skarsgård’s incredible transformation for the lead role as a Viking Berserker in the brand new movie, The Northman. Even with his “celebrity trainer” title (which he doesn’t love), Magnus is quick to say, “It's not who you train, it's how you train.”His Magnus Method training philosophy embraces the “ethos of an athlete.” This all-inclusive approach to performance includes an athlete’s intensity and structure, while also maintaining balance and energy. Time-zone travel, long days of filming, rehearsals, and the constant demands on a celebrity performer’s time means examining all aspects of fueling, rest and recovery. The same applies to the everyday lives of mere mortals.He encourages being open to learning new things and seeking out discomfort so you can grow. “Look at three things,” Magnus recommends. “One, what do I like to do? No. 2, what does my body need? No. 3, what do I want to master or get better at? That should create your weekly programming.”You already know, and Magnus will remind you, that there are absolutely no life shortcuts to being the superhero of your own life.In this conversation, you’ll find out how much time to spend on your workouts (not as much as you think). “What doesn’t happen in the first hour will not happen in the second,” he says frequently. Even for superheroes.Learn more about Magnus Lygdbäck’s journey from hockey player to celebrity trainer.Find out how you can improve your own performance on Magnus’s extensive YouTube channel.Get Magnus’ superhero training programs, nutrition guides, coaching and a community of like-minded people with the Magnus Method app. See Privacy Policy at and California Privacy Notice at
Today, we’re joined by second-time guest, Dr. Caroline Leaf, to talk about helping kids clean up their mental mess and be more resilient—all based on research from her latest book, How to Help Your Child Clean Up Their Mental Mess. In this episode, Dr. Caroline Leaf shares the best ways for parents to help their kids understand their emotions and build better habits.Dr. Leaf conducts ongoing research and clinical trials in the field of psychoneurobiology in order to improve mental health interventions, many of which she summarizes in this far reaching, informative conversation. We explore the impact of social media on kids’ anxiety, what parents can do to minimize the mental mess social media can make, and even how to rewire neural patterns it forms. We also dive into the myths of habit formation and how we can break down old habits to form better, new ones. Dr. Leaf’s expertise doesn't stop there. She also gives a comprehensive explanation of the five steps of the Neurocycle, a tool set for self-regulation and changing your internal programming.00:01:32 — The Dangers of Social Media & Minimizing Mental Messes• Giving coffee to kids• Danger Coffee:• The mental health crisis kids are facing today• Social media’s role in anxiety in kids• What is a mental mess?• Read: Cleaning Up Your Mental Mess• Avoiding a mental mess while using social media• Read: How to Help Your Child Clean Up Their Mental Mess• How to teach kids to go deep on topics they’re interested in• The science behind how long it takes to build or change a habit00:27:31 — Habit Hacking 101• The 5 Steps Neurocycle to rebuild neural networks• The myth of building habits in 21 days• Identifying patterns in habit formation for transforming and healing the brain• How the history of habit formation and brain neuroplasticity has evolved over time• The new standard of care and giving hopeful diagnoses• Empowering ourselves to be the driver of our own health00:54:37 — Helping Kids Build Resilience• Curiosity as a tool for building resilience in kids• The importance of learning how to self-regulate• How modeling the Neurocycle can help parents and children manage emotions• Why you should double down on what makes you weird• Teaching kids to question everything to filter out what’s real• Removing bias by connecting with others who aren't your age• Helping kids get good sleepResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: Read: How to Help Your Child Clean Up Their Mental MessRead: Cleaning Up Your Mental MessWebsite: drleaf.comFacebook: Dr. Caroline LeafInstagram: @drcarolineleafYouTube: Dr. Caroline LeafPodcast: CLEANING UP YOUR MENTAL MESS5 Steps of Neurocycle Can Clean Up Your Mental Mess – Dr. Caroline Leaf with Dave Asprey – #799The Human Upgrade is produced by Crate Media.See Privacy Policy at and California Privacy Notice at
IN THIS EPISODE OF THE HUMAN UPGRADE you’ll learn how to recognize your own sh*t and be a better partner in relationships. Want a sustainable partnership? Communicate and apologize; fight without fighting; identify codependent behavior (your own); and manage jealousy (also your own). This conversation gets into how you can let go of unrealistic ideals of how you think love and relationships should be and live fully in the present. You’ll also get tips on how to be emotionally responsible to people you love every day.Guest John Kim, a licensed marriage and family therapist, as well as a life coach, cracks his life into two big pieces… split on either side of what he calls “the great divide” of his own divorce several years ago. He did the whole “get a tattoo and a Harley” thing to find his way.He also combined what he learned in therapy school with life coaching and technology to be mobile and create online communities. He became known as an unconventional therapist, seeing clients at coffee shops, on hikes, or in a CrossFit box. He’s built a devoted following of fans who love the frank and authentic insights that he—as “The Angry Therapist”—freely shares on social media. TikTok’s his jam, with over 450K people tuning in for his “shot glass” bits of life wisdom.In his book, written with his romantic partner and fellow therapist Vanessa Bennett,  John takes a different (honest, humorous, raw) approach by dissecting his own relationship dynamic to bring clarity to yours. Each part of “IT’S NOT ME, IT’S YOU: Break the Blame Cycle, Relationship Better” gives you questions to ask yourself and practices to do. It’s a book that pushes you into doing and putting your newfound knowledge to IRL use. Here’s a sneak peek at a few of the Love Lessons (In a Shot Glass) you’ll find in “It’s Not Me, It’s You.”Love is not a battlefield. Your head is. If someone is unsure about you, it’s never worth the investment.Hold love, don’t grab it.Don’t stop believing (be Journey).Love is what teaches us how to live.See Privacy Policy at and California Privacy Notice at
Today's episode is an Upgrade Spotlight edition, where we bring someone on the show who has created something interesting. Our guest today is Dr. Myles Spar, a leading authority in personalized performance medicine as an author, teacher, researcher, TEDx talk speaker, advisor to NBA players, and an Ironman athlete. In today’s episode, Dr. Spar shares the vast range of benefits of Calroy Health Sciences products, many of which I use in my morning routine, including Arterosil and Vascanox. We talk about the science behind these formulations, and how they help support athletic performance, recovery, cardiovascular health, and even sexual function.If you’re interested in trying these products yourself, you can get a discount off a three-month supply of Arterosil and Vascanox at — Improve Cardiovascular Health with Vasconox• The correlation between nitric oxide and endurance athletics• Calroy Health Sciences:• Vascanox:• How nitric oxide supports vascular health• How to collaborate with your doctor00:13:02 — Spotlight on Nitric Oxide & Hydrogen Sulfide• Nitric oxide and aging• Three kinds of nitric oxide in the body• How nitric oxide helps sexual function• An explanation of hydrogen sulfide’s impact on the body00:20:46 — Why Investing in Quality Supplements is Worthwhile• Arterosil:• Why I invest in 84+ supplements for my morning regimen• The science behind Calroy products• The importance of recovery and optimizing the speed of recovery• Read: Smarter Not Harder• My supplement fix for POTS, Postural Orthostatic HypotensionResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: Get a discount off a three-month supply of Arterosil and Vascanox at drspar.comFacebook: Myles Spar, MDInstagram: @drsparLinkedin: @drsparYouTube: @mdsparThe Human Upgrade is produced by Crate Media.See Privacy Policy at and California Privacy Notice at
Today's episode is a special intervention episode where I work with a member of the Upgrade Collective, my mentorship and membership group, to help them get closer to achieving their health goals. This conversation is all about investigating member Nadya Green’s struggle to lose weight despite following a low carb diet and cycle syncing her eating habits. Nadya, originally from Russia, has spent her life pursuing an international career in the energy sector. She has worked as an engineer around the globe, including the UK, US, Australia, Egypt, Russia and now Sweden. Becoming a mom at 35 years old has made it ever so critical to be fit and to be able enjoy activities with her family, which is why biohacking and weight loss has become a centerpiece in her life. We talk about her lab results that point to potential gut issues, estrogen dominance, and mineral deficiencies leading to her cravings, and why her carbophobia may actually be working against her goals. I share with Nadya tools and tips to illustrate all the different pathways that you can use to get the results you want. So, if you're looking at what could be holding you back in your weight loss journey, tune in to hear the advice I gave Nadya about where she could be going wrong, and what to do to help her feel her best.Join the Upgrade Collective to get access to be in the live audience for all of my podcasts, with calls where we all get together and help each other biohack whatever needs biohacking, at 00:01:35 — Why A Low Carb Diet Might Not Help Your Weight Loss Goals• Nadya’s history with extreme fatigue, Hashimoto’s and carbophobia• The impact of the keto diet long-term on metabolism• Toxins related to PCOS and endometriosis• Read: Smarter Not Harder• Environmental & emotional causes of sugar cravings• Symptoms of having active yeast in your gut00:16:44— Combating Candida: Supplements, Medications & Lifestyle Solutions• Exploring the different ways to combat Candida• My hot take on pharmaceuticals• How to support your detox pathways while on pharmaceuticals• How Candida is related to a sensitivity to cow’s milk• Limiting sugar without eliminating it• Eating what you like in moderation and not being in a perfectionist trap• Cycle syncing your cravings and carbs00:32:05 — Eat to Feel Amazing: Spotlight On Protein & Minerals• Protein types and amount recommendations• The Bulletproof Diet:• Why new mothers need to pay more attention to their mineral levels• Tps for getting enough electrolytes and offsetting mineral deficiency• Why I recommend eliminating dairy to combat fatigue or brain fog• Helpful supplements for estrogen dominanceResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: Biohacking Conference: the Upgrade Collective: Human Upgrade is produced by Crate Media.See Privacy Policy at and California Privacy Notice at
Our guest today is a legendary thinker, author, and philosopher. Ken Wilber has spent decades understanding how humans are all interconnected with each other, decoding through dozens of beautifully written books, how we fit into the greater, massive, picture that is the expanding universe. He's an absolute pioneer, a visionary, and that barely scratches the surface of his work.He joins Dave to outline his newest book—Finding Radical Wholeness: The Integral Path to Unity, Growth, and Delights—and offers up a supporting stream of consciousness which rivals any that you’d find, on any podcast, in depth of insight and emotional impact. His words resonate with a truth and wonder which will leave you inspired from beginning to end, and well beyond.00:00:38 — Finding Radical Wholeness with Ken Wilber • Ken Wilber’s Amazon Author Page• Different ways to explain the general ideas of the world• Read: Finding Radical Wholeness: The Integral Path to Unity, Growth, and Delights• Achieving wholeness in our day-to-day• Ken’s first experience of wholeness with the universe• Does a dog have Buddha-nature?• Studying the work of D.T. Suzuki as a young boy• Read: Essays in Zen Buddhism by D.T. Suzuki• Oneness experiences as the core of spirituality• Considering satori as the most precious gift that humankind has00:18:09 — The Roles Biohacking & Brain Stimulation Play in Unity Experiences • Electromagnetic brain stimulation for ultimate reality experiences• How brain-mind machines work• Tap Into Your Brain’s Full Potential - Patrick Porter, Ph.D. #869• How Dave wrote The Bulletproof Diet in gamma state • What the mind does vs. what the heart does• Ken’s favorite advancements in technology • Questions remain with regard to quantum unity• Explaining the theta formless state• The Science of Changing Your Mind - Dr. Joe Dispenza #98000:38:10 — States of Emptiness & How To Get There • Teachings of Nagarjuna• Formulating the quantum principles• Why all forms of thinking are incomplete • The four-quadrant pronouns that make it all make sense• Basic tenets of integral theory• Shared objective views, social organism or a collective group• Going deep with Ken Wilber• Are we living in a simulation?• Fourth and fifth states of consciousness01:08:55 — This is Ken Wilber on Drugs & Nonduality• Psychedelic experiences vs. mystical oneness experiences • Drugs as a shortcut to masterful meditation• Ken’s bad trip• Stan Grof’s early LSD work • The Birth of LSD with Dr. Stanislav Grof, Father of Transpersonal Psychology - #428• Failures of the psychedelic revolution • Dave’s hand in the ayahuasca boom• Ken Wilber’s awe-inspiring perspective on nonduality • Read: Finding Radical Wholeness: The Integral Path to Unity, Growth, and Delights• Outline of Ken’s latest book • Stages of operational thinking• Introduction to systems theory • Appreciating the psychosomatic analysis of Fritz PerlsResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: Read: Finding Radical Wholeness: The Integral Path to Unity, Growth, and DelightsRead: Amazon Author Page YouTube: Integral LifeThe Human Upgrade is produced by Crate Media.See Privacy Policy at and California Privacy Notice at
In this episode of The Human Upgrade you’ll meet a holistic neurosurgeon who’s evolving spine care away from cutting. Dr. Marcella Madera’s integrative approaches to spine problems pair science with holistic healing modalities. This means way better healing for you.Dr. Madera’s innovations in spine treatments include the “Aqua Method,” where photobiomodulated platelet rich plasma meets functional tissue mobilization and movement. You’re going to get exciting new information about this effective form of regenerative medicine and find out if this treatment may be right for you. “It's a very nuanced discussion,” says Dr. Madera. “It's very patient specific. It's very injury specific.”“The term Aqua really gives a description of what we're trying to create in the body and that is more fluidity,” she explains. “And also, water, aqua, is pure. It’s intense at times, depending on the form. And it is soothing at times, depending on the form. And that is how our treatment goes.”Dr. Madera’s four-part system includes: Reveal, Restore, Revitalize, Revel. You could benefit whether you have an old or new injury, or chronic pain.During this episode, she explains how each part is interconnected and helps you heal your spine, or even knee, problems. The Aqua Method’s three-day immersive experience includes a full team of experts focused on your biology, your energy and your state of mind.Dr. Madera, a board-certified neurosurgeon, trained extensively in conventional medicine. Her expertise in spine care includes surgical treatments, approaches, and techniques for degenerative spine disease, spine tumors, and degenerative deformity. She started a private practice in in Austin, Texas where she combines her technical spine care with stem cell treatments and holistic modalities like herbs, energy modalities, Chinese healing practices, autogenic training and diet modification.More about Dr. Marcella Madera: She’s experienced in open surgery, minimally invasive surgery, endoscopic spine surgery, and regenerative/stem cell procedures. She’s been an assistant professor of Surgery at the University of Texas at Austin Dell Medical School. She also travelled throughout Europe and the U.S. to learn progressive endoscopic techniques and regenerative medicine practices. She completed a Spine Fellowship and faculty instructorship at Johns Hopkins School of Medicine.See Privacy Policy at and California Privacy Notice at
Comments (189)

Dorian C. Schiefelbein

In the development of cybersecurity of satellite European systems, an important stage is regularly tested What disadvantages in modern satellites can be useful to spies and enemy hackers?

May 28th

Kelly Matera

If you are looking to burn calories then less time equals less calories. So if that's your goal then this wouldn't be beneficial, correct?

Sep 26th


Hi Dave, You mentioned in this podcast that you do NOT recommend psyllium as prebiotic fiber - at the same time on other podcasts you're promoting which has psyllium as one of their main ingredients. I'm a bit confused. Could you please help me to clarify this? Should I avoid products as they have psyllium in it? Thx.

Aug 14th


I'm just wondering: if the infrared sauna heats the person up from the inside: 1. Then Why does a "cabin" needed to be built around it, why cannot it be just a wall panel, like the JOOVV 3.0 Red Light Therapy devices? 2. And if the "cabin" is indeed needless for the infrared Sauna, then why JOOVV or SUNLIGHTEN - or any other similar company don't build a device /wall panel which offers 2 in 1: both Red Light Therapy AND infrared sauna in one single device / single session? Would this be too difficult/expensive to build? Or would there be health risks to have infrared sauna and red light therapy session together, at the same time?

Aug 14th

Dwight Mattix

re: low T as a function of training intensity and recovery Highly recommend mark sisson's book primal endurance. Brad Kearns case presented in that book is right in line with this guy's experience.

May 26th

M Morr

watch soft white underbelly. tell them and the host of that show what you said in the peer's podcast about therapy. give them money to better their lives since you don't think they need some help. really disappointed in you Dave. you let me down. I will no longer praise you.

Jan 18th

M Morr

what you said about the therapy is so wrong and proves you are an not really a sufferer like you say. I followed you for years...years... not now. you have no idea what me and others have been through. You were fat and picked on, but what about a full trauma childhood, leaving you really mentally crippled. I liked you but now not so sure. you think anyone that had a awful upbringing or horrible experience can do it themselves. slight insult.

Jan 15th

M Morr

what you just said about the therapy is so wrong and proves you are an idiot. I followed you for yers...years... I am out. you have no idea what me and others have been through. wow. you are not in touch. thank you for showing me what type of person you are. I liked you but now no. you think anyone that had a awful upbringing or horrible experience can eR a carrot or spend your kind of money sitting in a tube of water and they get better. shame on you. someone last week said terrible things about you but I defended you but now what you Saud in the episode is an total insult.

Jan 14th

Dwight Mattix

really enjoyed this one. it continues to amaze me how otherwise intelligent well-informed people like the guest can remain so ignorant about this virus and the vaccine. I.e I e. overestimating the risk and uninformed about how useless and dangerous the vax has proven to be. not to mention completely uninformed about a middle or alternate path to addressing the public health issue. heaven forbid public health officials should encourage testing for vitamin d, inflammation and blood sugar regulation. or that they would advocate supplementation and holistic approaches to preparing oneself to win against the virus. heaven forbid they should advocate prophylactic treatment for those at high risk of exposure or infection. no way should this intelligent individual advocate for prophylactic use of proven effective early treatments

Oct 21st

Kevon Lindenberg

this is the first time someone has explained why memory palaces are useful in our day and age. time to clean off the vines.

Jul 25th

Maria Prado

That is so ualll conversation, i have a teen doughter, She had anorexia and i was trying teach her to make peace whit food with high fat diet is good for the brain and she used to feel less hunger less stressed . Learn with Dr Daniel Amen and i thought that was the best for her.. When she was at psychiatric clinic, they criticize my method i was begging for them not to give her white bread and sugary food becouse she gets into stress becouse od the craving, she also wants too, she keeping saying that she want to do fat diet and fell better this way, they dinied gave to her white flour and sugar and its not good for any those kids, They used every Tuesday teachs kids how to do candys and cakes... They didint exercised and sun shower only thru the window I was lost.. Sad.. puting my kid in sharks mouth.. Was in the best lisbon hospital at Portugal.. We are so far away.. Thank god that i found you and Peter Attia, Jason Fung Mark Hyman, Ben Bikman... 🙏

May 13th

Maria Prado

So precious.. Thanks 🙏💪

Apr 13th

Maria Prado

So interesting and nice topic, and very fun becouse last February I had 7 day fast on the beginning of the month and i also had 2 times 48 hours in the end of the month I did 5 day fast total I did 15 days without food i lost 5 kilos, and my period 😕 then I realize that I went to far.. Damm I felt so good.. So hard to me to lose weight, and my inflammation was not there anymore, Rsrsrs thanks one more time Dave 🙏

Apr 2nd

Maria Prado

Omg thank you very much, love and learning a lot with you and Dr bikman 🙏🙌❤️ gratitude

Mar 18th

jewels bach

😱This is mind-blowing. I'm listing to it while recovering from pituitary surgery.. can't wait to try 🙏

Feb 7th

Sameer Khan


Dec 28th

Dwight Mattix

this woman IS the problem

Dec 19th
Reply (2)


Great content but these two things will have me thinking twice about listening to another podcast:. Very disruptive noise of someone opening package, rummaging through contents, taping back up, crying paper, etcetera! Multi-tasking during a podcast is just rude!

Oct 9th

Amazing show!

Oct 5th

Sean Leveroos


Sep 28th
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