The Metabolic Link

On this week’s episode of The Metabolic Link, co-hosts Dr. Dominic D’Agostino, Dr. Angela Poff, and Victoria Field discuss two seemingly conflicting research studies exploring the effects of ketosis on muscle health in models of atrophy.Atrophy refers to the wasting of a body tissue or organ that occurs due to the degeneration of cells. Atrophy of vital tissues such as the skeletal muscle occurs in numerous pathological catabolic conditions, such as in cancer cachexia, motor neuron diseases, and following ischemic events, and it contributes greatly to morbidity and mortality in these patients. But skeletal muscle atrophy also occurs during aging. This is referred to as sarcopenia and is defined as an age-related, involuntary loss of skeletal muscle mass and strength. Its prevalence and impact in the elderly should make the prevention of sarcopenia a goal for all.Unsurprisingly, researchers are interested in designing methods to combat atrophy and sarcopenia. Due to the reported anti-catabolic metabolic and signaling properties of ketone bodies, researchers are studying how ketosis – either through the ketogenic diet or exogenous ketones – may play a therapeutic role in this condition. In their chat, the Metabolic Link co-hosts take a deep dive into two research papers that seem to produce conflicting results on the topic. But as always, the devil’s in the details, and the team discusses some illuminating points that highlight just how complex interpreting scientific research can be.Every Tuesday, we'll be sharing a new podcast episode that uncovers the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!Publications discussed:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9422126https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432582/You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel: Apple, Google, Spotify, Amazon Music, and BuzzsproutThanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

On this week’s episode of The Metabolic Link, Dr. Dominic D’Agostino is sitting down with world-renowned metabolic scientist, Ben Bikman, PhD, to explore the ins and outs of insulin resistance, Type 2 Diabetes Mellitus (T2DM), and ways to manage, and even reverse, both.In this discussion, Dr. Bikman makes a case for why testing fasting insulin should be a part of the diagnostic and treatment equation when addressing T2DM, the difference between pathological and physiological insulin resistance, and how insulin therapy affects metabolic physiology in T2DM. Dr. Bikman explains that while insulin is necessary for healthy living, it can elicit significant and harmful changes in tissue metabolic function when chronically elevated. Dr. D’Agostino and Dr. Bikman also dive into the relationship between triglycerides and insulin, and some of his latest research in the lab.Dr. Ben Bikman has a Ph.D. in Bioenergetics and completed a postdoctoral fellowship with the Duke-National University of Singapore in metabolic disorders. His research focus is to elucidate the molecular mechanisms that mediate the disruption that causes and accompanies metabolic disorders, such as obesity, type 2 diabetes, and dementia. Driven by his academic training, he is currently exploring the contrasting roles of insulin and ketones as key drivers of metabolic function. He is a highly accomplished scientist with numerous publications in high impact journals and international presentations.Every Tuesday, we'll be sharing a new podcast episode that uncovers the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel: Apple, Google, Spotify, Amazon Music, and BuzzsproutThanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

In this episode, The Metabolic Link Hosts Dr. Dominic D’Agostino, Dr. Angela Poff, and Victoria Field review recent research exploring the use of ketogenic metabolic therapy in Parkinson’s Disease and Mental Illness.The first study discussed investigates the effects of a ketogenic diet applied prior to versus after the onset of Parkinson’s disease in an animal model. Parkinson’s disease is a highly prevalent disease, with over 6 million people worldwide who suffer from it. We understand the fundamental feature of Parkinson’s disease is characterized by the loss of dopaminergic neurons, but researchers can’t yet fully explain why this loss occurs. It’s thought that neuro-inflammation might be a potential culprit and this study explores tackling such inflammation head-on with ketosis.The groups also dives into the exciting and rapidly developing field of metabolic psychiatry, including the potential use of ketogenic therapy in treating mental illness. They discuss a review article that highlights the emerging evidence supporting the use of ketogenic therapy in serious mental illness which covers several case studies in even the most challenging of mental illnesses, including psychosis. The mechanisms behind why this therapy might improve mental health are also discussed.Please find all research references below. Every Tuesday, we'll be sharing a new episode that uncovers the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in. You can also listen to this episode by clicking one of the links below: Research papers discussed in episode:The Anti-Inflammatory Effect of Preventive Intervention with Ketogenic Diet Mediated by the Histone Acetylation of mGluR5 Promotor Region in Rat Parkinson's Disease Model: A Dual-Tracer PET Study: https://pubmed.ncbi.nlm.nih.gov/36105302/Ketogenic Therapy in Serious Mental Illness: Emerging Evidence: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387764/Schizophrenia, gluten, and low-carbohydrate, ketogenic diets: a case report and review of the literature: https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-6-10Ketogenic diet in the treatment of schizoaffective disorder: Two case studies: https://pubmed.ncbi.nlm.nih.gov/28162810/The ketogenic diet and remission of psychotic symptoms in schizophrenia: Two case studies: You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel: Apple, Google, Spotify, Amazon Music, and BuzzsproutThanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

On this week’s episode of The Metabolic Link, we’re sitting down with Oncology Dietitian, L.J. Amaral for a fascinating conversation that explores implementing metabolic therapy, such as the ketogenic diet, within oncology. In this episode, we dive into why she started using metabolic therapy for cancer, how she implements it with patients at Cedars-Sinai, and the kind of results she’s seen in using it. We also cover some of the most difficult obstacles in starting a ketogenic diet in the face of a cancer diagnosis, and how Amaral helps patients overcome such challenges.L.J. Amaral, M.S., R.D., CSO, is a Clinical Research Dietitian who is board certified in oncology nutrition. She works at the Cedars Sinai Cancer Institute in Los Angeles, CA. She is involved in many clinical trials looking at diet/lifestyle within cancer, such as researching the efficacy of the Ketogenic Diet as an adjunct to standard of care therapy for CNS malignancies. Amaral specializes in cancer nutrition for cancer prevention, during treatment, for survivorship, in therapeutic Ketogenic diets and in oncology nutrition research and hosts Nourishing Nutrition Kitchen weekly on social media where she makes easy, cancer fighting recipes. Every Tuesday, we'll be sharing a new episode that uncovers the very latest research on metabolic health and therapy. Please like this video and subscribe to our channel for the latest science on metabolic health and therapy. You can also listen to this episode and others by clicking one of the links below.You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel: Apple, Google, Spotify, Amazon Music, and BuzzsproutThanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

On this week’s episode of The Metabolic Link, we’re sitting down with world-renowned Fasting and Longevity Researcher, Valter Longo, PhD, to explore a variety of topics related to metabolic health including the impact of protein consumption on longevity, the latest research on the fasting mimicking diet in diabetes and Alzheimer’s, the future of metabolic therapies, and how both our host of The Metabolic Link, Dr. Dominic D'Agostino, and Dr. Longo utilize fasting and approach healthy eating in their own lives. Dr. Valter Longo has thirty years of experience in the field of longevity and healthy eating. He is the Director of the Longevity Institute at the University of Southern California – Leonard Davis School of Gerontology, Los Angeles, and the Director of the Longevity and Cancer Program at the IFOM, The Italian Foundation for Cancer Research (FIRC) Institute of Molecular Oncology in Milan, Italy. He is the author of the best seller “The Longevity Diet” and the 2 Italian books “Alla tavola della longevità” (“At the Table of Longevity”), and “La longevità inizia da bambini” (“Longevity Begins in Childhood”). Professor Longo is also the scientific director of the Create Cures Foundation and the Valter Longo Foundation. In 2018, TIME Magazine named Professor Longo as one of the 50 most influential people in health care for his research on fasting-mimicking diets as a way to improve health and prevent diseases.Every Tuesday, we'll be sharing a new episode that uncovers the very latest research on metabolic health and therapy. Please like this video and subscribe to our channel for the latest science on metabolic health and therapy. You can also listen to this episode and others by clicking one of the links below: You can find us on all your major podcast players here: Apple: https://podcasts.apple.com/us/podcast/the-metabolic-link/id1666125722Google:https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5idXp6c3Byb3V0LmNvbS8yMTAzMjY5LnJzcw==Spotify: https://open.spotify.com/show/59ExyA5s9LLC1jYHXLFi3eAmazon Music: https://music.amazon.com/podcasts/78fa2414-2c36-4992-9bc2-05ef01239889/the-metabolic-link?refMarker=nullBuzzsprout: https://themetaboliclink.buzzsprout.com/You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel: Apple, Google, Spotify, Amazon Music, and BuzzsproutThanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

On this week's episode of The Metabolic Link, we’re sitting down with Longevity and Epigenetics Researcher, Lucia Aronica, PhD, to explore the science behind how our DNA and diet dance together to determine our metabolic health. We also dive into how nutrition affects our epigenetics, how an individual’s genetic makeup influences which diet is most suitable for them, and what biomarkers can be utilized to assess response to diet. Dr. Lucia Aronica, Ph.D., is Lecturer at Stanford University, Genomics R&D Lead at Metagenics Inc., and an acclaimed speaker in the field of personalized lifestyle medicine. Her research and teaching focus on nutrigenomics — the science of how nutrition, genetics, and epigenetics interact with each other to impact our health and longevity. Dr. Aronica established the first certificate program in nutrigenomics at Stanford and helped thousands of professionals implement nutrigenomics in their business. This interview was recorded at Metabolic Health Summit in partnership with The Charlie Foundation in May of 2022. Find Dr. Aronica’s upcoming courses at https://draronica.com/ Every Tuesday, we'll be sharing a new episode that uncovers the very latest research on metabolic health and therapy. Please like this video and subscribe to our channel for the latest science on metabolic health and therapy. You can also listen to this episode and others by clicking one of the links below: You can find us on all your major podcast players here: Apple: https://podcasts.apple.com/us/podcast... Google: https://podcasts.google.com/feed/aHR0...Spotify: You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel: Apple, Google, Spotify, Amazon Music, and BuzzsproutThanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

In this week’s episode of The Metabolic Link, hosts Dr. Dominic D’Agostino, Dr. Angela Poff, and Victoria Field explore metabolic therapy for cancer and why some researchers believe that the altered metabolism that drives tumor progression might be successfully targeted with novel metabolic focused approaches such as the ketogenic diet. They specifically review and evaluate a 2022 case study detailing the use of a calorie restricted ketogenic diet complementary to standard of care therapies in a patient with lung cancer that had metastasized to the brain. This emerging field of research is promising, but still in its infancy with many nuances to consider. Tune in for a thought-provoking discussion on this fascinating topic!Every Tuesday, we'll be sharing a new episode that uncovers the very latest research on metabolic health and therapy. Please click the links below to listen, follow, or subscribe, and if you like this episode, please consider sharing it or writing us a review. We hope you enjoy!Apple: https://podcasts.apple.com/.../the-metabolic.../id1666125722 Google: https://podcasts.google.com/.../aHR0cHM6Ly9mZWVkcy5idXp6c... Spotify: https://open.spotify.com/show/59ExyA5s9LLC1jYHXLFi3e... Amazon Music: https://music.amazon.com/.../78fa2414.../the-metabolic-link Buzzsprout: https://themetaboliclink.buzzsprout.com YouTube: https://www.youtube.com/@MetabolicHealthSummitPublication discussed in this episode: https://pubmed.ncbi.nlm.nih.gov/36059366/You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel: Apple, Google, Spotify, Amazon Music, and BuzzsproutThanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

On this week’s episode of The Metabolic Link, host Dr. Dominic D’Agostino sits down with Dr. Molly Maloof to explore the importance of metabolic health for women and how to optimize it. They dive into biotechnology, fasting, the ketogenic diet, hormone testing, and the importance of social connection for metabolic and mental wellbeing. They also dive into a common struggle many women face: trying to lose weight or improve health while under a lot of stress… and Dr. Maloof even shares her personal experience with it during the pandemic.Dr. Maloof has first-hand experience in transforming her health and the health of her patients and she has dedicated her career to researching new, innovative ways to help people live a healthier lifestyle and improve their healthspan. For three years she has taught a course on Healthspan at Stanford University. She is on the cutting edge of personalized medicine, changing how we look at everything from digital-health technologies to psychedelic medicine and has high-profile entrepreneurs, investors, and technology executives on optimizing their health. Through her book, “The Spark Factor,” she focuses her unique philosophy to help women biohack their biology to live a happier, healthier, and more energized life.Every Tuesday, we'll be sharing a new episode that uncovers the very latest research on metabolic health and therapy. Please click the links below to listen, follow, or subscribe, and if you like this episode, please consider sharing it or writing us a review. We hope you enjoy!Apple: https://podcasts.apple.com/.../the-metabolic.../id1666125722 Google: https://podcasts.google.com/.../aHR0cHM6Ly9mZWVkcy5idXp6c... Spotify: https://open.spotify.com/show/59ExyA5s9LLC1jYHXLFi3e... Amazon Music: https://music.amazon.com/.../78fa2414.../the-metabolic-link Buzzsprout: https://themetaboliclink.buzzsprout.com YouTube: https://youtu.be/NxxGeoclei8You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel: Apple, Google, Spotify, Amazon Music, and BuzzsproutThanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

On today's episode of The Metabolic Link podcast, we're sitting down with Harvard Psychiatrist, Christopher Palmer, MD, to explore the common thread between brain energy metabolism and mental health. In this intimate interview, we dive into how Dr. Palmer became a pioneer in the field of metabolic psychiatry, the role of metabolic therapy in mental health and how its impacted the lives of his patients, and much more. Dr. Palmer is a psychiatrist and researcher working at the interface of metabolism and mental health who has been advocating the use of the medical ketogenic diet in the treatment of psychiatric disorders. This interview was recorded at Metabolic Health Summit in partnership with The Charlie Foundation in May of 2022.Every Tuesday, we'll be sharing a new episode that uncovers the very latest research on metabolic health and therapy. Please click the links below to listen, follow, or subscribe, and if you like this episode, please consider sharing it or writing us a review. We hope you enjoy!Apple: https://podcasts.apple.com/.../the-metabolic.../id1666125722 Google: https://podcasts.google.com/.../aHR0cHM6Ly9mZWVkcy5idXp6c...Spotify: https://open.spotify.com/show/59ExyA5s9LLC1jYHXLFi3eAmazon Music: https://music.amazon.com/.../78fa2414.../the-metabolic-linkBuzzsprout: https://themetaboliclink.buzzsprout.comYouTube: https://youtu.be/NxxGeoclei8You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel: Apple, Google, Spotify, Amazon Music, and BuzzsproutThanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

In this episode, The Metabolic Link Hosts Dr. Dominic D’Agostino, Dr. Angela Poff, and Victoria Field dive into the central link of metabolism that exists between most chronic illnesses, and how research in this growing field is unveiling new, promising strategies to optimize health and delay, prevent, or treat the development of disease.You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel: Apple, Google, Spotify, Amazon Music, and BuzzsproutThanks for listening! Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.