#486 Infertility in Clinical Practice: A Primary Care Approach With Dr Brindha Bavan
Digest
This podcast features Dr. Brenda Bavan, an REI specialist, discussing infertility diagnosis and treatment. The episode begins by defining infertility according to ASRM guidelines and highlighting its prevalence (affecting 1 in 6-8 couples). The discussion then delves into the initial workup for male infertility, focusing on semen analysis (volume, concentration, motility, morphology) and its interpretation. The limitations of semen analysis and the importance of patient history and genetic screening are also addressed. The female factor workup is systematically reviewed, covering the reproductive tract (vagina, cervix, uterus, tubes, ovaries), age, lifestyle factors, and pre-pregnancy health optimization. Ovarian reserve assessment methods (AMH, FSH, estradiol, AFC) are explained, along with their interpretation. Unexplained infertility, its prevalence, and treatment options (IUI with superovulation and IVF) are discussed, including cost and long-term implications. The podcast concludes by addressing the financial burden of infertility treatments, insurance coverage, and the crucial role of mental health support for patients. Practical advice is offered to primary care physicians on coding and navigating insurance complexities to improve patient access to care.
Outlines

Infertility Workup and Treatment: An Overview
This episode introduces Dr. Bavan and provides an overview of infertility, including its definition, prevalence, and the importance of inclusive language and open communication. It also briefly touches upon the initial workup for both male and female infertility.

Male and Female Infertility Workup
This section details the initial workup for male infertility (semen analysis, patient history, genetic screening) and female infertility (systematic review of the reproductive tract, age, lifestyle factors).

Ovarian Reserve, Unexplained Infertility, and Treatment Options
This section covers ovarian reserve assessment (hormonal testing and AFC), unexplained infertility, and treatment options including IUI and IVF, along with cost and insurance considerations.

Cost, Insurance, and Patient Support in Infertility Care
This section focuses on the financial aspects of infertility treatment, insurance navigation, and the importance of mental health support for patients, offering practical advice for PCPs.
Keywords
Infertility
Inability to conceive after a year of unprotected intercourse (under 35) or six months (35+). Can be due to male, female, or combined factors, or unexplained. Treatment options include IUI and IVF.
Semen Analysis
Lab test evaluating sperm parameters: volume, concentration, motility, morphology. Used in male infertility workup. Abnormal results may indicate need for further investigation or referral to a urologist.
Ovarian Reserve
A woman's remaining egg supply. Assessed via AMH, FSH, estradiol levels, and antral follicle count (AFC) on ultrasound. Declines with age.
IUI (Intrauterine Insemination)
Fertility treatment where sperm is directly placed into the uterus near the time of ovulation. Often used in cases of unexplained infertility or mild male factor issues.
IVF (In Vitro Fertilization)
Fertility treatment involving egg retrieval, fertilization in a lab, and embryo transfer. Used for various infertility causes, including severe male factor, tubal disease, and unexplained infertility.
Unexplained Infertility
Infertility with no identifiable cause, comprising approximately one-third of infertility cases.
Infertility Treatment Costs
The significant financial burden associated with infertility treatments and the role of insurance coverage.
Q&A
What are the key components of a semen analysis, and how are the results interpreted?
Semen analysis assesses volume, concentration, motility, and morphology of sperm. Normal ranges vary, but low counts in any of these areas may indicate male factor infertility. Referral to a urologist may be necessary for further evaluation.
How is ovarian reserve assessed, and what are the implications of low ovarian reserve?
Ovarian reserve is assessed via AMH, FSH, estradiol levels, and AFC. Low levels suggest a diminished egg supply, potentially impacting fertility. However, low AMH doesn't always predict inability to conceive.
What are the first-line treatment options for unexplained infertility?
First-line treatment is typically IUI with superovulation. If unsuccessful after several cycles, IVF is often considered. The decision depends on factors like age, cost, and patient preference.
What are some ways PCPs can support patients navigating infertility?
PCPs can play a crucial role by normalizing conversations about infertility, performing initial screenings, ordering relevant tests (AMH, FSH, estradiol, semen analysis), and providing counseling and emotional support. They can also help patients understand and navigate insurance coverage complexities.
Show Notes
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Show Segments
- Intro
- Case from Kashlak
- Definitions of infertility
- Male factor infertility evaluation
- History
- Semen analysis
- lifestyle
- Female factor infertility evaluation
- Anatomical approach
- Basic testing
- More advanced testing
- Unexplained infertility treatment
- Success of infertility treatments
- Financial impact/advocacy
- Oocyte preservation
- Outro
Credits
- Producer, Writer, Show notes, Cover Art, Infographics: Molly Heublein MD
- Hosts: Molly Heublein MD, Era Kryzhanovskaya MD
- Reviewer: Emi Okamoto MD
- Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP
- Technical Production: PodPaste
- Guest: Brindha Bavan MD
Disclosures
Dr. Brindha Bavan reports no relevant financial disclosures. The Curbsiders report no relevant financial disclosures.
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