DiscoverHow I Invest with David WeisburdE157: DA Wallach: Spotting Genius in Elon & Zuck's Early Days
E157: DA Wallach: Spotting Genius in Elon & Zuck's Early Days

E157: DA Wallach: Spotting Genius in Elon & Zuck's Early Days

Update: 2025-04-22
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This podcast features DA, a successful venture capitalist with an unusual background. He recounts his early fascination with AI, influenced by Elon Musk and Demis Hassabis, citing AI's mastery of complex video games as a pivotal moment. His entrepreneurial journey began with a rock band, leading to a record deal and a move to Los Angeles. A chance encounter at Facebook led to his involvement with Spotify, where he served as artist-in-residence. DA emphasizes the importance of networking and surrounding himself with high-caliber individuals. His partnership with Ron Burkle resulted in Inevitable Ventures. He discusses the challenges of transitioning into venture capital, including developing a robust investment process and learning from mistakes. His investment focus has shifted towards healthcare and biotech, driven by the potential for technological advancements to revolutionize medicine. He compares portfolio construction strategies in biotech and traditional venture capital, highlighting the higher risk and probabilistic nature of biotech investments and the importance of diversification. DA's investment philosophy centers on continuous learning, surrounding himself with inspiring individuals, and a contrarian approach to identifying undervalued opportunities.

Outlines

00:00:00
Early AI Recognition & SpaceX Investment

DA's early awareness of AI's potential, influenced by Elon Musk and Demis Hassabis, and his early investment in SpaceX, driven by Musk's vision and reusable rocket technology.

00:04:24
From Musician to Investor: Spotify & Networking

DA's journey from a rock musician to a record deal, his involvement with Spotify as artist-in-residence, and his philosophy of building relationships with high-caliber individuals.

00:22:32
Inevitable Ventures & Venture Capital Learning

DA's collaboration with Ron Burkle, the creation of Inevitable Ventures, and the challenges and learning process involved in transitioning into venture capital.

00:33:17
Transition to Biotech Investing & Portfolio Strategies

DA's shift towards healthcare and biotech investing, driven by advancements in life sciences, and a comparison of portfolio construction strategies in biotech versus traditional venture capital.

Keywords

Artificial Intelligence (AI)


The simulation of human intelligence processes by machines, especially computer systems. Recent advancements include breakthroughs in deep learning and its application in complex problem-solving.

Venture Capital (VC)


Investment in early-stage companies with high growth potential. VCs provide funding in exchange for equity, playing a crucial role in innovation and economic growth.

Biotech Investing


Investing in companies developing new drugs, medical devices, and diagnostic tools. High risk, high reward due to the probabilistic nature of drug development and the potential for transformative impact on healthcare.

SpaceX


A private aerospace manufacturer and space transportation services company. Known for its reusable rocket technology and ambitious space exploration goals.

Spotify


A popular digital music, podcast, and video streaming service.

Elon Musk


Entrepreneur and innovator known for his involvement in SpaceX, Tesla, and other ventures.

Portfolio Construction


The process of selecting and allocating assets within an investment portfolio to achieve specific financial goals while managing risk. Diversification is key, especially in high-risk asset classes.

Contrarian Investing


An investment strategy that goes against the prevailing market sentiment. It involves identifying undervalued assets or opportunities that the majority of investors are overlooking.

Q&A

  • What is your investment philosophy, and how does your background as a recording artist influence your approach?

    My philosophy centers on continuous learning and surrounding myself with inspiring people. My artistic background instilled a strong sense of taste and confidence in my judgment, which translates to identifying compelling investment opportunities.

  • How do you identify and assess promising investment opportunities in the competitive biotech space?

    We focus on overlooked gems, often smaller companies in less-saturated geographic areas or therapeutic areas. We prioritize rigorous scientific analysis and a long-term perspective, looking beyond short-term trends.

  • What are the key differences between your portfolio construction strategies in traditional venture capital and biotech investing?

    Biotech investing involves higher inherent risk due to the probabilistic nature of drug development. Therefore, we prioritize diversification and an equal-weighted portfolio initially, doubling down on promising investments over time.

  • What advice would you give to aspiring investors seeking to break into the venture capital field?

    Develop a strong investment process, learn from both successes and failures, and cultivate a contrarian mindset. Be comfortable with being different and willing to go against the grain. Most importantly, focus on building strong relationships and learning from those around you.

Show Notes

D.A. Wallach’s journey is one of the most unconventional paths in venture capital. He went from fronting a rock band discovered by Kanye West and Pharrell, to investing in Spotify, SpaceX, and founding a biotech VC firm reshaping human medicine. In this episode, we dive into his evolution—from artist to investor—and what he’s learned from being in the room with Mark Zuckerberg, Elon Musk, and Ron Burkle.
D.A. shares why great investing is an act of taste, how he earned his first big break with Ron Burkle at Inevitable Ventures, and why he believes biotech is the most exciting place to invest over the next decade. We also discuss how aesthetic intuition applies to investing, how to think in second and third order effects, and what it really means to be contrarian when contrarianism has gone mainstream.


Highlights:



  • How D.A. invested in SpaceX after meeting Elon Musk socially in LA

  • Lessons from working with Spotify, including his invented role as “artist-in-residence”

  • What he saw in Facebook in the early days and how he used it to grow his band

  • How Kanye West and Pharrell discovered his music and launched his career

  • The backstory behind raising capital for Spotify and meeting Ron Burkle

  • What made Ashton Kutcher and D.A. uniquely valuable investors at the time

  • Why he pivoted from tech into life sciences and started a healthcare-focused VC firm

  • The importance of developing aesthetic judgment as an investor

  • How to think about portfolio construction in biotech vs. software

  • Why investing is mostly about people—and what pattern recognition D.A. uses

  • The subtle power of learning from failures and “almost mistakes”

  • How to be truly contrarian in an environment where contrarianism is trendy


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Guest Bio:
D.A. Wallach is a venture capital investor and former recording artist. Discovered by Pharrell Williams while at Harvard, he toured with artists like Lady Gaga and Blink-182 and released music through Interscope and Capitol Records. In 2011, he shifted to investing, backing companies like Spotify, SpaceX, Ripple, and Neuralink. Today, he focuses on biotech and healthcare as co-founder of Time BioVentures. Named to Forbes' “30 Under 30” and Fast Company’s “100 Most Creative People,” D.A. also co-founded the Franca Fund for preventive genomics and appeared in the film La La Land.


Our Podcast now receives more than 300,000 downloads a month. Are you interested in sponsoring an episode? Please email David Weisburd at david@weisburdcapital.com.


We’d like to thank @Republic for sponsoring this episode!


#VentureCapital #VC #Startups #OpenLP #AssetManagement


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Sponsor:
Republic is the leading global investment platform making premier private market opportunities accessible to all investors. With over $3 billion deployed across its network of investment platforms, funds, and affiliated firms, Republic opens the door to new asset classes typically reserved for institutional investors such as—private equity, venture capital, and even sports teams and your favorite film producers.


All securities, including the Hamilton Lane’s Private Infrastructure Fund, are offered through affiliate Republic Broker-Dealer, OpenDeal Broker LLC Member FINRA & SiPC. All securities come with specific risks not limited to a total loss of your investment. Past performance is not indicative of future results. Please review the risks specific to this investment on the HLPIF deal page hosted on http://republic.com/hlpif.


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Stay Connected:
Twitter:
David Weisburd: @dweisburd


LinkedIn:
David Weisburd: https://www.linkedin.com/in/dweisburd/
D.A. Wallach: https://www.linkedin.com/in/dawallach/


Links
Time BioVentures: https://www.timebioventures.com/


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Questions or topics you want us to discuss on How I Invest? Email us at david@weisburdcapital.com.




(0:00 ) Episode preview
(2:00 ) Elon Musk's early views on AI and building SpaceX
(4:18 ) Transition from music to investing and collaboration with Spotify
(7:17 ) Leveraging Facebook for a band’s success and networking strategies
(12:06 ) Mark Zuckerberg's early projects and the rise of Facebook
(14:39 ) Contrarianism and its role in modern investing
(19:22 ) How a music background influences investment decisions
(22:32 ) Working with Ron Burkle and Inevitable Ventures
(27:17 ) The journey of learning venture capitalism
(30:10 ) Assessing higher-order effects in investments
(31:52 ) The critical importance of investing in people
(33:17 ) Diving into healthcare and biotech investing
(36:46 ) Portfolio strategies in biotech versus traditional venture capital
(39:38 ) How to compete with major biotech firms
(44:40 ) The advantages of being surrounded by top performers
(46:58 ) Learning from near-misses and investment failures
(48:25 ) Closing remarks
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E157: DA Wallach: Spotting Genius in Elon & Zuck's Early Days

E157: DA Wallach: Spotting Genius in Elon & Zuck's Early Days

David Weisburd