DiscoverHuberman LabThe Effects of Cannabis (Marijuana) on the Brain & Body
The Effects of Cannabis (Marijuana) on the Brain & Body

The Effects of Cannabis (Marijuana) on the Brain & Body

Update: 2022-10-0350


In this episode, I discuss cannabis (aka marijuana), including the biological mechanisms underlying its effects on the mind and body, its known medical applications, its impact on libido, creativity, hunger, hormones and more. I also cover the known adverse health consequences of chronic and even acute (one-time) use and the factors that determine if cannabis is helpful or harmful. Additionally, I detail how the various strains of cannabis: sativa, indica and hybrid strains, can produce such divergent effects depending on the strain type, THC-to-CBD ratio, total dosage, and frequency of use. I review why cannabis can impact speech patterns and one’s propensity to develop anxiety/depression during and after use and, in some individuals, paranoia. As the legal landscape for cannabis is rapidly evolving, this episode should interest a wide audience, including former/current cannabis users, those in the medical, sports, law enforcement, and educational communities and, of course, children, teenagers, and parents.

For the full show notes, visit

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(00:00:00 ) Cannabis (Marijuana)

(00:00 5:02 ) Sponsor: LMNT

(00:07:03 ) Tool: Non-Sleep Deep Rest (NSDR), Sleep & Anxiety

(00:15:08 ) Cannabis Strains, Psychoactive Compounds: THC & CBD

(00:19:34 ) Sativa vs. Indica, Stimulant vs. Relaxation Effects

(00:25:55 ) Hybrid Cannabis Strains, Type 1, 2 & 3 Strains

(00:31:56 ) Naturally Occurring Receptors: Nicotinic & Cannabinoid Receptors (CB1)

(00:35:18 ) Sponsor: AG1

(00:40:35 ) THC, CBD vs. Endogenous Cannabinoids, Dependence

(00:43:14 ) Endogenous Cannabinoids, Cannabinoid Receptors & Nervous System Function

(00:53:07 ) Biological Effects of Cannabis

(00:56:29 ) Cannabis Sativa & Subjective Effects: Mood, Stress, Alertness, Paranoia

(01:04:58 ) Cannabis Indica & Subjective Effects, Memory, Dosage

(01:09:41 ) Brain Areas Affected by THC & CBD, Side Effects

(01:16:08 ) Creativity: Convergent vs. Divergent Thinking & Dopamine

(01:26:41 ) Does Cannabis Increase Creativity?

(01:35:08 ) Chronic Cannabis Use & Changes in Speech Patterns

(01:46:46 ) Cannabis & Libido, Dopamine & Prolactin

(01:56:55 ) Cannabis & Hormones: Prolactin, Testosterone, Estrogen & Fertility

(02:06:53 ) Smoking/Vaping Tobacco or Cannabis & Negative Health Consequences

(02:10:06 ) Avoiding Cannabis During Pregnancy/Breastfeeding, Fetal Neural Development

(02:18:13 ) Negative Health Consequences of Cannabis, Anxiety & Depression, Tolerance

(02:25:57 ) Cannabis Use & Adolescence/Young Adulthood, Predisposition to Psychosis

(02:34:36 ) Adolescent Cannabis Use: Brain Development & Mental Health Disorders

(02:41:44 ) Cannabis & Pain Management, Divergent Effects of Cannabis

(02:44:54 ) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Huberman Lab Premium, Momentous Supplements, Neural Network Newsletter, Instagram, Twitter, Facebook, LinkedIn

 Title Card Photo Credit: Mike Blabac


Comments (7)

Connon Berry

A few months ago, I hit my foot against the wall of the pool. I had excruciating pain and a swollen leg. My doctor advised me to know more about difference between hash and weed from this source I decided to order it. I used it for a few days, so the swelling has gone down and there's no pain in my leg anymore. I urge you to check the details of this cream and try it as I think it will help you in these cases

May 8th

Adam Haynes

I want to get know difference between hash and weed better. Does anybody know anything about it?

May 8th

Sasha Teller

I'd say that nowadays, many people turn to cannabis because it's actually a great way to cope with stress and anxiety. I have no idea what I'd do if I didn't discover, cannabis edibles are great. And I think it should be more widespread because health benefits of cannabis are worth knowing.

Mar 1st

Elizabeth Gorgon

In recent years, attitudes towards the use of marijuana in the world have begun to change quite rapidly. Many of us have already appreciated the medicinal properties of cannabis, and now you can easily find dispensaries near you here

Jan 31st

Adtonitus Maiusculus

this mf could've cut this down to an hour if he didn't specify ingestion of cannabis can include smoking, vaping, or edibles every single time he mentioned it

Oct 14th
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The Effects of Cannabis (Marijuana) on the Brain & Body

The Effects of Cannabis (Marijuana) on the Brain & Body

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