DiscoverHuberman LabThe Science & Treatment of Bipolar Disorder | Episode 82
The Science & Treatment of Bipolar Disorder | Episode 82

The Science & Treatment of Bipolar Disorder | Episode 82

Update: 2022-07-259


In this episode, I explain the biology, symptoms, causes and types of bipolar disorder (sometimes called bipolar depression). I discuss neuroplasticity and how the brain normally regulates mood, energy, and perceptions; then, I contrast that with the biology of bipolar disorder, which is characterized by extremes of energy and mood, e.g., mania and depression. I outline the mechanisms through which bipolar disorder manifests in the brain, including deficits of interoception and reduced connections between the parietal and limbic systems. I also outline how treatment options (such as lithium) work in part through homeostatic plasticity.’ I discuss not only lithium but also the treatment of bipolar with ketamine, different talk therapies, electroconvulsive therapy, transcranial magnetic stimulation, and nutraceuticals, including Omega-3 and Inositol supplementation. This episode should interest anyone who has or knows someone with bipolar disorder and, more broadly, those interested in how the brain works to create a balance between thoughts, energy levels, focus, and mood.

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For the full show notes, visit


(00:00:00 ) Bipolar Disorder

(00:02:23 ) Momentous Supplements

(00:03:42 ) Tool: Appetite Suppression & GLP-1, Parallel Pathways, Yerba Mate

(00:10:23 ) InsideTracker, ROKA, Blinkist

(00:14:24 ) Prevalence & Severity of Bipolar Disorder

(00:16:30 ) Bipolar Disorder I, Diagnostic Criteria of Mania

(00:28:58 ) Bipolar Disorder II, Individual Variability

(00:33:07 ) Bipolar I vs. Bipolar II: Manic, Depressive & Symptom-Free States

(00:38:20 ) Consequences of Bipolar Disorder, Heritability

(00:46:53 ) Bipolar Disorder vs. Borderline Personality Disorder

(00:51:51 ) Mania & Depression, Negative Impacts

(00:53:06 ) History of Lithium Treatment

(01:02:44 ) Lithium Treatment & Side-Effects

(01:05:05 ) Effects of Lithium: BDNF, Anti-inflammatory & Neuroprotection

(01:10:10 ) Neural Circuits of Bipolar Disorder, Interoception, Hyper- vs. Hypoactivity

(01:17:11 ) Neural States & Mania, Parietal Lobe & Limbic System

(01:22:58 ) Homeostatic Plasticity, Synaptic Scaling, Lithium & Ketamine

(01:36:00 ) Talk Therapies: Cognitive Behavioral Therapy, Family-Focused Therapy, Interpersonal & Social Rhythm Therapy

(01:43:18 ) Electroconvulsive Therapy (ECT), Transcranial Magnetic Stimulation (rTMS)

(01:48:01 ) Psylocibin, Cannabis

(01:51:50 ) Lifestyle Support, Supplements: Inositol & Omega-3 Fatty Acids

(02:03:31 ) Omega-3s, Membrane Fluidity & Neuroplasticity

(02:06:44 ) Mania, Creativity & Occupations

(02:15:33 ) Bipolar Disorder: Diagnosis, Neural Circuits & Treatment

(02:17:45 ) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter

Title Card Photo Credit: Mike Blabac


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The Science & Treatment of Bipolar Disorder | Episode 82

The Science & Treatment of Bipolar Disorder | Episode 82

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