DiscoverLifespan with Dr. David SinclairThe Science of Keeping the Brain Healthy | Episode 7
The Science of Keeping the Brain Healthy | Episode 7

The Science of Keeping the Brain Healthy | Episode 7

Update: 2022-02-1621


In this episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante dissect the topic of brain aging. They explore evidence suggesting that the brain ages more slowly than other parts of the body and highlight how cognitive function is impacted by aging. Different interventions aimed at preserving brain health are also discussed, including a plant-based diet, exercise, metformin, NAD boosters, and sufficient sleep.

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To stay up to date with David's work to democratize biological age testing and insights, visit


(00:00:00 ) Introducing Episode Seven: Aging of the Brain

(00:04:39 ) Thanking the Sponsors

(00:07:38 ) Ex-differentiation as a Driver of Aging

(00:09:22 ) The Brain Ages Slowly

(00:14:17 ) Cognitive Function and Plasticity

(00:17:44 ) Three Longevity Pathways: mTOR, AMPK, and Sirtuins

(00:23:26 ) Plant-based Diets and B-vitamins

(00:28:32 ) Homocysteine, Plaque, and Vasculature

(00:32:35 ) Fatty Acids

(00:35:48 ) Physical Activity

(00:39:14 ) Metformin

(00:46:02 ) NAD Boosters

(00:50:33 ) Increasing Blood Flor

(00:53:20 ) Sleep

(00:58:02 ) Overall Message: Keep your Brain Healthy

(00:58:50 ) Next Week’s Episode and the Future of Medicine

(01:01:21 ) Options for Subscription for Support

For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.

Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

Comments (2)

Emilia Gray

Lack of vitamin D is a common phenomenon, mainly due to the lack of a nutritious and balanced diet. Deficiency is also caused by diseases of the gastrointestinal tract, frequent stress and nervous tension. But don’t worry about this, because everything can be corrected thanks to this vitamin complex

Nov 8th

Ali Raisi

Thank you guys

Feb 20th








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The Science of Keeping the Brain Healthy | Episode 7

The Science of Keeping the Brain Healthy | Episode 7

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