While high levels of cholesterol are often associated with an increased risk of cardiovascular disease, the paradox arises when studies reveal unexpected relationships between low cholesterol levels and certain health issues.

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References: 

Wang, S.-S. et al. Cholesterol paradox in the community-living old adults: is higher better? J. Geriatr. Cardiol. 20, 837–844 (2023).
 

Murata, S. et al. Blood biomarker profiles and exceptional longevity: comparison of centenarians and non-centenarians in a 35-year follow-up of the Swedish AMORIS cohort. GeroScience 1–10 (2023) doi:10.1007/s11357-023-00936-w.

Time Stamps:

00:00 High cholesterol, as you age, is protective.

01:10 Higher HDL and higher total cholesterol is associated with greater longevity and reduction in death from cardiovascular disease.

02:00 Middle aged men have a risk from high LDL and high total cholesterol.

02:25 Low Cholesterol is associated with mortality from stroke, heart disease and cancer.

05:40 Your LDL goes up as you become more metabolically healthy.

05:50 Triglycerides enrich cholesterol particles in the insulin resistant

06:15 Test your ApoB to A1 ratio. HDL and triglycerides should be close to 1:1.

07:00 Low cholesterol is a risk factor for poor prognosis for cancer.