DiscoverHuberman LabAdderall, Stimulants & Modafinil for ADHD: Short- & Long-Term Effects
Adderall, Stimulants & Modafinil for ADHD: Short- & Long-Term Effects

Adderall, Stimulants & Modafinil for ADHD: Short- & Long-Term Effects

Update: 2023-05-2923
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Description

In this episode, I explain how medications such as Adderall, Ritalin, Vyvanse and other stimulants work to increase focus and treat attention-deficit/hyperactivity disorder (ADHD). I explain the brain circuits involved in focus and the key roles dopamine and norepinephrine play in their regulation. Then I explain how stimulants such as Adderall and Vyvanse can increase focus and reduce hyperactivity in kids or adults with ADHD, and how and why Ritalin and other medications (e.g., Modafinil, Guanfacine) may work better for some. I explain the long-term effects of ADHD medications on height, cardiovascular health, hormones, predisposition to addiction and psychosis, and whether these treatments can be used and then stopped. I also discuss the immense individual variation in dosage sensitivity for these medications and the negative side-effects that occur from recreational use. This episode ought to benefit anyone with ADHD, their parents, those on ADHD medications or anyone curious about how these medications work.

For the full show notes, visit hubermanlab.com.

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Timestamps

(00:00:00 ) Stimulants & Attention-Deficient/Hyperactivity Disorder (ADHD)

(00:03:21 ) Sponsors: Maui Nui, ROKA, HVMN

(00:06:35 ) The Brain-Body Contract

(00:07:22 ) Attention, Prefrontal Cortex & ADHD

(00:16:27 ) Stimulants “Sympathomimetics”

(00:21:29 ) Adderall, Dopamine & Norepinephrine

(00:25:58 ) Sympathomimetics, Dopamine & Norepinephrine

(00:31:05 ) Sponsor: AG1

(00:32:20 ) Vyvanse is Timed-Release D-Amp

(00:36:36 ) Ritalin, Concerta

(00:40:10 ) Dopamine & “Noise Reduction”; Norepinephrine & “Signal Amplification”

(00:45:28 ) ADHD: Focus, Hyperactivity & Impulsivity; Drug Selection & Dose

(00:50:57 ) How do Stimulants ‘Calm’ ADHD?

(00:54:48 0 Neuroplasticity & Neuromodulators

(00:58:06 ) Kids, ADHD Diagnosis & Treatment; Predispose Addiction?

(01:04:02 ) Sponsor: InsideTracker

(01:05:12 ) ADHD Medications: Individuality, Doses, Tapering & Long-Term Use

(01:13:28 ) Medication & Long-Term Effects: Height, Cardiovascular Risk, Alcohol

(01:19:32 ) Cortisol & Hormones

(01:27:45 ) Psychosis & Addiction; Methamphetamine

(01:38:20 ) Recreational Use, Addiction & Psychosis; Habituation

(01:42:30 ) Drug Holidays; Ritalin & Long-Term Effects

(01:45:35 ) Modafinil, Armodafinil; Side-Effects

(01:53:03 ) Guanfacine, Alcohol

(01:58:03 ) ADHD Medications

(02:00:26 ) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter

Title Card Photo Credit: Mike Blabac

Disclaimer

Comments (2)

Marzieh Sadat

Thank you, it was really helpful👌

Jul 5th
Reply

Miks

small precision: amphetamins are prescribed in first intention in the US, but in Europe it is methylphenidate that is largely prescribed first. Some europeean countries don't even allow Vyvanse prescriptions, not sure for Adderall.

May 29th
Reply
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Adderall, Stimulants & Modafinil for ADHD: Short- & Long-Term Effects

Adderall, Stimulants & Modafinil for ADHD: Short- & Long-Term Effects

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